Muscle oxygen supply impairment during maximal exercise in patients undergoing dialysis therapy

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-10-09 DOI:10.1016/j.resp.2023.104169

Amal Machfer , Sémah Tagougui , Nadia Fekih , Hayfa Ben Haj Hassen , Hassen Ibn Hadj Amor , Mohamed Amine Bouzid , Hamdi Chtourou

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Abstract

This study aimed to investigate whether Chronic Kidney Disease (CKD) influences O₂ supply including O₂ delivery and release to the active muscles during maximal physical exercise. Twelve CKD patients undergoing dialysis therapy (HD group) and twelve healthy adults (CTR group) performed an incremental exercise test to determine maximal oxygen uptake (VO_2peak). Throughout the exercise, near-infrared spectroscopy allowed the investigation of changes in oxyhemoglobin (∆O₂Hb), deoxyhemoglobin (∆HHb), and total hemoglobin (∆THb) in the vastus lateralis muscle. VO_2peak was significantly lower in HD group. In addition, HD patients had impaired changes in muscular oxygenation (∆HHb and ∆O₂Hb) and blood volume (∆THb) during the exercise (p < 0.05). Moreover, a positive correlation was observed between VO_2peak and muscle blood volume (∆THb) in both groups (p < 0.05). This study provides the first evidence that HD patients displayed lower VO_2peak and blunted muscular deoxyhemoglobin increase during exercise. This result supports the hypothesis of an increase in oxygen affinity and/or mitochondrial dysfunction in this population.

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接受透析治疗的患者在最大运动量期间肌肉氧供应受损。

本研究旨在调查慢性肾脏疾病（CKD）是否影响O2供应，包括在最大限度的体育锻炼中O2向活动肌肉的输送和释放。12名接受透析治疗的CKD患者（HD组）和12名健康成年人（CTR组）进行了增量运动测试，以确定最大摄氧量（VO2peak）。在整个运动过程中，近红外光谱可以研究股外侧肌中氧合血红蛋白（∆O2Hb）、脱氧血红蛋白（∆HHb）和总血红蛋白（∆THb）的变化。HD组的VO2峰值显著降低。此外，HD患者在运动过程中肌肉氧合（∆HHb和∆O2Hb）和血容量（∆THb）的变化受损（两组中的p2peak和肌肉血容量（ΔTHb））（运动过程中的p2peak和减弱的肌肉脱氧血红蛋白增加）。这一结果支持了该人群中氧亲和力增加和/或线粒体功能障碍的假设。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.