Muscle oxygen supply impairment during maximal exercise in patients undergoing dialysis therapy

IF 1.9 4区医学 Q3 PHYSIOLOGY

Respiratory Physiology & Neurobiology Pub Date : 2023-10-09 DOI:10.1016/j.resp.2023.104169

Amal Machfer , Sémah Tagougui , Nadia Fekih , Hayfa Ben Haj Hassen , Hassen Ibn Hadj Amor , Mohamed Amine Bouzid , Hamdi Chtourou

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Abstract

This study aimed to investigate whether Chronic Kidney Disease (CKD) influences O₂ supply including O₂ delivery and release to the active muscles during maximal physical exercise. Twelve CKD patients undergoing dialysis therapy (HD group) and twelve healthy adults (CTR group) performed an incremental exercise test to determine maximal oxygen uptake (VO_2peak). Throughout the exercise, near-infrared spectroscopy allowed the investigation of changes in oxyhemoglobin (∆O₂Hb), deoxyhemoglobin (∆HHb), and total hemoglobin (∆THb) in the vastus lateralis muscle. VO_2peak was significantly lower in HD group. In addition, HD patients had impaired changes in muscular oxygenation (∆HHb and ∆O₂Hb) and blood volume (∆THb) during the exercise (p < 0.05). Moreover, a positive correlation was observed between VO_2peak and muscle blood volume (∆THb) in both groups (p < 0.05). This study provides the first evidence that HD patients displayed lower VO_2peak and blunted muscular deoxyhemoglobin increase during exercise. This result supports the hypothesis of an increase in oxygen affinity and/or mitochondrial dysfunction in this population.

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接受透析治疗的患者在最大运动量期间肌肉氧供应受损。

本研究旨在调查慢性肾脏疾病（CKD）是否影响O2供应，包括在最大限度的体育锻炼中O2向活动肌肉的输送和释放。12名接受透析治疗的CKD患者（HD组）和12名健康成年人（CTR组）进行了增量运动测试，以确定最大摄氧量（VO2peak）。在整个运动过程中，近红外光谱可以研究股外侧肌中氧合血红蛋白（∆O2Hb）、脱氧血红蛋白（∆HHb）和总血红蛋白（∆THb）的变化。HD组的VO2峰值显著降低。此外，HD患者在运动过程中肌肉氧合（∆HHb和∆O2Hb）和血容量（∆THb）的变化受损（两组中的p2peak和肌肉血容量（ΔTHb））（运动过程中的p2peak和减弱的肌肉脱氧血红蛋白增加）。这一结果支持了该人群中氧亲和力增加和/或线粒体功能障碍的假设。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Respiratory Physiology & Neurobiology 医学-呼吸系统

CiteScore

4.80

自引率

8.70%

发文量

104

审稿时长

54 days

期刊介绍： Respiratory Physiology & Neurobiology (RESPNB) publishes original articles and invited reviews concerning physiology and pathophysiology of respiration in its broadest sense. Although a special focus is on topics in neurobiology, high quality papers in respiratory molecular and cellular biology are also welcome, as are high-quality papers in traditional areas, such as: -Mechanics of breathing- Gas exchange and acid-base balance- Respiration at rest and exercise- Respiration in unusual conditions, like high or low pressure or changes of temperature, low ambient oxygen- Embryonic and adult respiration- Comparative respiratory physiology. Papers on clinical aspects, original methods, as well as theoretical papers are also considered as long as they foster the understanding of respiratory physiology and pathophysiology.