The Effect of Curcumin on the Gut-Brain Axis: Therapeutic Implications.

IF 3.3 3区 医学 Q2 CLINICAL NEUROLOGY
Ayesheh Enayati, Aida Soghi, Alexandra E Butler, Manfredi Rizzo, Amirhossein Sahebkar
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引用次数: 0

Abstract

The gut-brain axis describes the bidirectional communication between the gut, the enteric nervous system, and the central nervous system. The gut-brain axis has attracted increasing attention owing to its regulatory effect on dysbiosis and a wide range of related diseases. Several types of nutrients, such as curcumin, have been proposed as regulators of the dysbiotic state, and preclinical experiments have suggested that curcumin is not only beneficial but also safe. This review focuses on the interplay between curcumin and the gut microbiota. Moreover, it provides a comprehensive review of the crosstalk between the gut-brain axis and disease, whilst also discussing curcumin-mediated gut-brain axis-dependent and -independent signaling about modulation of gut microbiota dysbiosis. This will help to define the utility of curcumin as a novel therapeutic agent to regulate intestinal microflora dysbiosis.

姜黄素对肠脑轴的影响:治疗意义。
肠脑轴描述了肠道、肠神经系统和中枢神经系统之间的双向交流。肠脑轴由于其对微生态失调和一系列相关疾病的调节作用而引起越来越多的关注。有几种类型的营养素,如姜黄素,被认为是失调状态的调节因子,临床前实验表明姜黄素不仅有益,而且安全。这篇综述的重点是姜黄素和肠道微生物群之间的相互作用。此外,它对肠脑轴与疾病之间的相互作用进行了全面的综述,同时还讨论了姜黄素介导的肠脑轴依赖性和非依赖性信号传导对肠道微生物群失调的调节。这将有助于确定姜黄素作为一种新型治疗剂在调节肠道微生物群失调方面的作用。
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来源期刊
Journal of Neurogastroenterology and Motility
Journal of Neurogastroenterology and Motility GASTROENTEROLOGY & HEPATOLOGY-CLINICAL NEUROLOGY
CiteScore
6.30
自引率
8.80%
发文量
96
期刊介绍: Journal of Neurogastroenterology and Motility (J Neurogastroenterol Motil) is a joint official journal of the Korean Society of Neurogastroenterology and Motility, the Thai Neurogastroenterology and Motility Society, the Japanese Society of Neurogastroenterology and Motility, the Indian Motility and Functional Disease Association, the Chinese Society of Gastrointestinal Motility, the South East Asia Gastro-Neuro Motility Association, the Taiwan Neurogastroenterology and Motility Society and the Asian Neurogastroenterology and Motility Association, launched in January 2010 after the title change from the Korean Journal of Neurogastroenterology and Motility, published from 1994 to 2009.
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