Real-world Prescription Patterns and Patient Satisfaction Regarding Maintenance Therapy of Gastroesophageal Reflux Disease: An Observational, Cross-sectional, Multicenter Study.

IF 3.3 3区 医学 Q2 CLINICAL NEUROLOGY
Cheal Wung Huh, Nak Hoon Son, Young Hoon Youn, Da Hyun Jung, Min Kyung Kim, Eun Jeong Gong, Kyu Chan Huh, Seung Young Kim, Moo In Park, Ju Yup Lee, Joong Goo Kwon, Jae Hak Kim, Cheol Min Shin, Kee Wook Jung, Su Jin Hong, Hee Man Kim, Suck Chei Choi, Hye-Kyung Jung, Hyun Jin Kim, Kwang Jae Lee
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引用次数: 0

Abstract

Background/aims: Gastroesophageal reflux disease (GERD) is a common chronic gastrointestinal disorder that typically requires long-term maintenance therapy. However, little is known about patient preferences and satisfaction and real-world prescription patterns regarding maintenance therapy for GERD.

Methods: This observational, cross-sectional, multicenter study involved patients from 18 referral hospitals in Korea. We surveyed patients who had been prescribed proton pump inhibitors (PPIs) for GERD for at least 90 days with a minimum follow-up duration of 1 year. The main outcome was overall patient satisfaction with different maintenance therapy modalities.

Results: A total of 197 patients were enrolled. Overall patient satisfaction, patient preferences, and GERD health-related quality of life scores did not significantly differ among the maintenance therapy modality groups. However, the on-demand therapy group experienced a significantly longer disease duration than the continuous therapy group. The continuous therapy group demonstrated a lower level of awareness of potential adverse effects associated with PPIs than the on-demand therapy group but received higher doses of PPIs than the on-demand therapy group. The prescribed doses of PPIs also varied based on the phenotype of GERD, with higher doses prescribed for non-erosive reflux disease than erosive reflux disease.

Conclusion: Although overall patient satisfaction did not significantly differ among the different PPI maintenance therapy modality groups, awareness of potential adverse effects was significantly different between the on-demand and continuous therapy groups.

胃食管反流病维持治疗的真实处方模式和患者满意度:一项观察、横断面、多中心研究。
背景/目的:胃食管反流病(GERD)是一种常见的慢性胃肠道疾病,通常需要长期维持治疗。然而,关于GERD维持治疗的患者偏好、满意度和现实世界的处方模式知之甚少。方法:这项观察性、横断面、多中心研究涉及来自韩国18家转诊医院的患者。我们调查了服用质子泵抑制剂治疗胃食管反流病至少90天、最短随访时间为1年的患者。主要结果是患者对不同维持治疗方式的总体满意度。结果:共有197名患者入选。维持治疗模式组的总体患者满意度、患者偏好和GERD健康相关生活质量评分没有显著差异。然而,按需治疗组经历的疾病持续时间明显长于持续治疗组。与按需治疗组相比,持续治疗组对PPI相关的潜在不良反应的认识水平较低,但接受的PPI剂量高于按需治疗。PPIs的处方剂量也因GERD的表型而异,非侵蚀性反流病的处方剂量高于侵蚀性反流病。结论:尽管不同PPI维持治疗模式组的总体患者满意度没有显著差异,但按需治疗组和持续治疗组对潜在不良反应的认识存在显著差异。
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来源期刊
Journal of Neurogastroenterology and Motility
Journal of Neurogastroenterology and Motility GASTROENTEROLOGY & HEPATOLOGY-CLINICAL NEUROLOGY
CiteScore
6.30
自引率
8.80%
发文量
96
期刊介绍: Journal of Neurogastroenterology and Motility (J Neurogastroenterol Motil) is a joint official journal of the Korean Society of Neurogastroenterology and Motility, the Thai Neurogastroenterology and Motility Society, the Japanese Society of Neurogastroenterology and Motility, the Indian Motility and Functional Disease Association, the Chinese Society of Gastrointestinal Motility, the South East Asia Gastro-Neuro Motility Association, the Taiwan Neurogastroenterology and Motility Society and the Asian Neurogastroenterology and Motility Association, launched in January 2010 after the title change from the Korean Journal of Neurogastroenterology and Motility, published from 1994 to 2009.
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