Local and systemic autoimmune manifestations linked to hepatitis A infection.

IF 1.3 4区医学 Q4 GASTROENTEROLOGY & HEPATOLOGY

Acta gastro-enterologica Belgica Pub Date : 2023-07-01 DOI:10.51821/86.3.11299

M Doulberis, A Papaefthymiou, S A Polyzos, E Vardaka, M Tzitiridou-Chatzopoulou, D Chatzopoulos, A Koffas, V Papadopoulos, F Kyrailidi, J Kountouras

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引用次数: 1

Abstract

Hepatitis A virus (HAV) represents a global burdening infectious agent causing in the majority of cases a self-limiting acute icteric syndrome, the outcome is related to the hepatic substrate and the potential pre-existing damage, whereas a plethora of extra-hepatic manifestations has also been reported. Despite the absence of post- HAV chronicity it has been associated with an additional burden on existing chronic liver diseases. Moreover, the induced immune response and the antigenic molecular mimicry are considered as triggering factors of autoimmunity with regional and distal impact. Diseases such as autoimmune hepatitis, Guillain-Barré syndrome, rheumatoid arthritis, Still's syndrome, Henoch-Schönlein purpura, autoimmune hemolytic anemia, antiphospholipid syndrome, systematic lupus erythematosus or cryoglobulinemic vasculitis have been described in patients with HAV infection. Although the exact mechanisms remain unclear, this review aims to accumulate and clarify the pathways related to this linkage.

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与甲型肝炎感染相关的局部和全身自身免疫表现。

甲型肝炎病毒（HAV）是一种全球性的负担传染源，在大多数情况下会导致自限性急性黄疸综合征，其结果与肝脏基质和潜在的预先存在的损伤有关，而也有大量肝外表现的报道。尽管没有甲型肝炎后的慢性病，但它与现有慢性肝病的额外负担有关。此外，诱导的免疫反应和抗原分子模拟被认为是具有区域和远端影响的自身免疫的触发因素。HAV感染患者中出现了自身免疫性肝炎、格林-巴利综合征、类风湿性关节炎、斯蒂尔综合征、过敏性紫癜、自身免疫性溶血性贫血、抗磷脂综合征、系统性红斑狼疮或冷球蛋白血症血管炎等疾病。尽管确切的机制尚不清楚，但本综述旨在积累和阐明与这种联系相关的途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta gastro-enterologica Belgica Medicine-Gastroenterology

CiteScore

2.30

自引率

20.00%

发文量

期刊介绍： The Journal Acta Gastro-Enterologica Belgica principally publishes peer-reviewed original manuscripts, reviews, letters to editors, book reviews and guidelines in the field of clinical Gastroenterology and Hepatology, including digestive oncology, digestive pathology, as well as nutrition. Pure animal or in vitro work will not be considered for publication in the Journal. Translational research papers (including sections of animal or in vitro work) are considered by the Journal if they have a clear relationship to or relevance for clinical hepato-gastroenterology (screening, disease mechanisms and/or new therapies). Case reports and clinical images will be accepted if they represent an important contribution to the description, the pathogenesis or the treatment of a specific gastroenterology or liver problem. The language of the Journal is English. Papers from any country will be considered for publication. Manuscripts submitted to the Journal should not have been published previously (in English or any other language), nor should they be under consideration for publication elsewhere. Unsolicited papers are peer-reviewed before it is decided whether they should be accepted, rejected, or returned for revision. Manuscripts that do not meet the presentation criteria (as indicated below) will be returned to the authors. Papers that go too far beyond the scope of the journal will be also returned to the authors by the editorial board generally within 2 weeks. The Journal reserves the right to edit the language of papers accepted for publication for clarity and correctness, and to make formal changes to ensure compliance with AGEB’s style. Authors have the opportunity to review such changes in the proofs.