Arabidopsis leaf-expressed AGAMOUS-LIKE 24 mRNA systemically specifies floral meristem differentiation

IF 8.3 1区生物学 Q1 PLANT SCIENCES

New Phytologist Pub Date : 2023-09-27 DOI:10.1111/nph.19293

Nien-Chen Huang, Huan-Chi Tien, Tien-Shin Yu

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引用次数: 0

Abstract

Plants can record external stimuli in mobile mRNAs and systemically deliver them to distal tissues to adjust development. Despite the identification of thousands of mobile mRNAs, the functional relevance of mobile mRNAs remains limited.
Many mobile mRNAs are synthesized in the source cells that perceive environmental stimuli, but specifically exert their functions upon transportation to the recipient cells. However, the translation of mobile mRNA-encoded protein in the source cells could locally activate downstream target genes. How plants avoid ectopic functions of mobile mRNAs in the source cells to achieve tissue specificity remains to be elucidated.
Here, we show that Arabidopsis AGAMOUS-LIKE 24 (AGL24) is a mobile mRNA whose movement is necessary and sufficient to specify floral organ identity. Although AGL24 mRNA is expressed in vegetative tissues, AGL24 protein exclusively accumulates in the shoot apex. In leaves, AGL24 proteins are degraded to avoid ectopically activating its downstream target genes.
Our results reveal how selective protein degradation in source cells provides a strategy to limit the local effects associated with proteins encoded by mobile mRNAs, which ensures that mobile mRNAs specifically trigger systemic responses only in recipient tissues.

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拟南芥叶片表达AGAMOUS-LIKE 24信使核糖核酸系统地指定花分生组织分化。

植物可以在移动信使核糖核酸中记录外部刺激，并系统地将其传递到远端组织以调节发育。尽管已经鉴定出数千种可移动的信使核糖核酸，但移动信使核糖核酸的功能相关性仍然有限。许多可移动的信使核糖核酸是在感知环境刺激的源细胞中合成的，但在转运到受体细胞时特异性地发挥其功能。然而，源细胞中移动信使核糖核酸编码蛋白的翻译可以局部激活下游靶基因。植物如何避免源细胞中移动信使核糖核酸的异位功能以实现组织特异性仍有待阐明。在这里，我们发现拟南芥AGAMOUS-LIKE 24（AGL24）是一种可移动的信使核糖核酸，其移动对于确定花器官的身份是必要的和充分的。尽管AGL24mRNA在营养组织中表达，但AGL24蛋白仅在茎尖积累。在叶片中，AGL24蛋白被降解以避免异位激活其下游靶基因。我们的研究结果揭示了源细胞中的选择性蛋白质降解如何提供一种策略来限制与移动mRNA编码的蛋白质相关的局部效应，这确保了移动mRNA仅在受体组织中特异性地触发系统反应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

New Phytologist 生物-植物科学

自引率

5.30%

发文量

728

期刊介绍： New Phytologist is an international electronic journal published 24 times a year. It is owned by the New Phytologist Foundation, a non-profit-making charitable organization dedicated to promoting plant science. The journal publishes excellent, novel, rigorous, and timely research and scholarship in plant science and its applications. The articles cover topics in five sections: Physiology & Development, Environment, Interaction, Evolution, and Transformative Plant Biotechnology. These sections encompass intracellular processes, global environmental change, and encourage cross-disciplinary approaches. The journal recognizes the use of techniques from molecular and cell biology, functional genomics, modeling, and system-based approaches in plant science. Abstracting and Indexing Information for New Phytologist includes Academic Search, AgBiotech News & Information, Agroforestry Abstracts, Biochemistry & Biophysics Citation Index, Botanical Pesticides, CAB Abstracts®, Environment Index, Global Health, and Plant Breeding Abstracts, and others.