Effects of betaine supplementation on inflammatory markers: a systematic review and meta-analysis of randomised controlled trials.

IF 3.5 2区农林科学 Q2 FOOD SCIENCE & TECHNOLOGY

International Journal of Food Sciences and Nutrition Pub Date : 2023-11-01 Epub Date: 2023-11-15 DOI:10.1080/09637486.2023.2257906

Jiaoyang Xu, Zizheng Nie, Xinyi Qiu, Jianyun Zhang, Shufen Han

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Abstract

Several studies have suggested that betaine is closely related to inflammatory biomarkers that contribute to the development of metabolic diseases, but the effect remains controversial. This meta-analysis aimed to assess the effects of betaine supplementation on inflammatory markers based on randomised controlled trials (RCTs). PubMed, Web of Science and ResearchGate databases were searched up to March 2023. A total of 6 RCTs with 7 intervention trials involving 277 participants were included. Betaine supplementation led to a slight reduction in levels of circulating IL-1β of 0.65 pg/mL (95% CI, -1.23 to -0.06) with high heterogeneity (I² = 95%). Betaine produced a small but nonsignificant reduction in levels of circulating CRP (0.33 mg/L; 95% CI, -1.79 to 1.14), IL-6 (0.47 pg/mL; 95% CI, -1.13 to 0.18) and TNF-α (0.25 pg/mL; 95% CI, -0.98 to 0.48). The present meta-analysis does not provide sufficient evidence to conclude that betaine supplementation improved the inflammation state.

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补充甜菜碱对炎症标志物的影响：随机对照试验的系统综述和荟萃分析。

几项研究表明，甜菜碱与导致代谢性疾病发展的炎症生物标志物密切相关，但其影响仍存在争议。这项荟萃分析旨在基于随机对照试验（RCT）评估补充甜菜碱对炎症标志物的影响。PubMed、Web of Science和ResearchGate数据库的搜索截止到2023年3月。共纳入6项随机对照试验和7项干预试验，涉及277名参与者。补充甜菜碱可使循环IL-1β水平略微降低0.65 pg/mL（95%CI，-1.23至-0.06），具有高度异质性（I2=95%）。Betaine使循环CRP水平略有下降，但并不显著（0.33 mg/L；95%CI，-1.79至1.14）、IL-6（0.47 pg/mL；95%可信区间-1.13至0.18）和TNF-α（0.25 pg/mL；95%CI，-0.98至0.48）。目前的荟萃分析没有提供足够的证据来得出补充甜菜碱改善炎症状态的结论。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Food Sciences and Nutrition 工程技术-食品科技

CiteScore

7.50

自引率

2.60%

发文量

审稿时长

1 months

期刊介绍： The primary aim of International Journal of Food Sciences and Nutrition is to integrate food science with nutrition. Improvement of knowledge in human nutrition should always be the final objective of submitted research. It''s an international, peer-reviewed journal which publishes high quality, original research contributions to scientific knowledge. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.