Development and In Vitro Evaluation of Aceclofenac Buccal Film.

Current drug discovery technologies Pub Date : 2024-01-01 DOI:10.2174/0115701638262447230920061222

Samah Hamed Almurisi, Ayah Mohammed, Farah Qassem, Heba Jehad, Asma Jassim, Khater Al-Japairai, Rana M F Sammour

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Abstract

Aim: This study aimed to formulate and characterize aceclofenac buccal film formulations made of different polymers and evaluate the effects of polymer type on buccal film properties.

Materials and methods: Five polymer types, namely hydroxypropyl methylcellulose (HPMC), sodium carboxymethylcellulose (SCMC), polyvinyl alcohol (PVA), Eudragit S100, and Eudragit SR100, were used to prepare aceclofenac buccal film formulation either separately or combined by solvent-casting method. These formulations were evaluated in terms of physical appearance, folding test, film weight and thickness, drug content, percentage of elongation, moisture uptake, water vapor permeability, and in vitro drug release.

Results: The addition of Eudragit polymer in most of the produced buccal films was unacceptable with low folding endurance. However, the dissolution profile of buccal films made from PVA and Eudragit SR100 provided a controlled drug release profile.

Conclusion: Buccal films can be formulated using different polymers either individually or in combination to obtain the drug release profile required to achieve a desired treatment goal. Furthermore, the property of the buccal films depends on the type and concentration of the polymer used.

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Aceclofenac口腔粘膜的制备及体外评价。

目的：本研究旨在制备和表征由不同聚合物制成的醋氯芬酸口腔膜制剂，并评估聚合物类型对口腔膜性能的影响。材料和方法：采用羟丙基甲基纤维素（HPMC）、羧甲基纤维素钠（SCMC）、聚乙烯醇（PVA）、优德拉吉S100和优德拉吉SR100五种聚合物，分别或结合溶剂浇铸法制备醋氯芬酸口腔膜制剂。对这些制剂的物理外观、折叠试验、薄膜重量和厚度、药物含量、伸长率、吸湿性、水蒸气渗透性和体外药物释放进行了评估。结果：在大多数生产的口腔粘膜中添加Eudragit聚合物是不可接受的，并且耐折性低。然而，由PVA和Eudragit SR100制成的口腔膜的溶解特性提供了受控的药物释放特性。结论：可以单独或组合使用不同的聚合物配制口腔膜，以获得实现所需治疗目标所需的药物释放曲线。此外，颊膜的性质取决于所用聚合物的类型和浓度。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Current drug discovery technologies

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