Cordycepin, a bioactive compound from Cordyceps spp., moderates Alzheimer’s disease-associated pathology via anti-oxidative stress and autophagy activation

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2024-05-03 DOI:10.1080/10286020.2023.2258797

Natchadaporn Soraksa , Nudjanad Heebkaew , Wilasinee Promjantuek , Phongsakorn Kunhorm , Palakorn Kaokean , Nipha Chaicharoenaudomung , Parinya Noisa

引用次数: 0

Abstract

Alzheimer’s causes cognitive dysfunction. This study investigated the neuro-promoting effects of cordycepin on amyloid-beta precursor protein (APP) synthesis in human neuroblastoma SH-SY5Y cells. Cordycepin was found to boost SH-SY5Y cell proliferation and decreased AD pathology. APP, PS1, and PS2 were downregulated whereas ADAM10 and SIRT1 were upregulated by cordycepin. Cordycepin also reduced APP secretion in a dose-dependent manner. Cordycepin alleviated oxidative stress by the upregulation of GPX and SOD, as well as autophagy genes (LC3, ATG5, and ATG12). Cordycepin activity was also found to be SIRT1-dependent. Therefore, cordycepin may relieve the neuronal degeneration caused by APP overproduction, and oxidative stress.

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虫草素是一种来自虫草属的生物活性化合物，通过抗氧化应激和自噬激活调节阿尔茨海默病相关病理。

阿尔茨海默病会导致认知功能障碍。本研究探讨了虫草素对人神经母细胞瘤SH-SY5Y细胞淀粉样蛋白β前体蛋白（APP）合成的神经促进作用。虫草素可促进SH-SY5Y细胞增殖，减少AD病理。虫草素下调APP、PS1和PS2，而上调ADAM10和SIRT1。虫草素还以剂量依赖的方式减少APP的分泌。虫草素通过上调GPX和SOD以及自噬基因（LC3、ATG5和ATG12）来减轻氧化应激。虫草素活性也被发现是SIRT1依赖性的。因此，虫草素可以缓解APP过度产生和氧化应激引起的神经元变性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.