Host-phage interactions and modeling for therapy.

3区 生物学 Q2 Biochemistry, Genetics and Molecular Biology
Joshua Williams, Nathan Burton, Gurneet Dhanoa, Antonia P Sagona
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引用次数: 0

Abstract

Phage are drivers of numerous ecological processes on the planet and have the potential to be developed into a therapy alternative to antibiotics. Phage at all points of their life cycle, from initiation of infection to their release, interact with their host in some manner. More importantly, to harness their antimicrobial potential it is vital to understand how phage interact with the eukaryotic environment in the context of applying phage for therapy. In this chapter, the various mechanisms of phage interplay with their hosts as part of their natural life cycle are discussed in depth for Gram-positive and negative bacteria. Further, the literature surrounding the various models utilized to develop phage as a therapeutic are examined, and how these models may improve our understanding of phage-host interactions and current progress in utilizing phage for therapy in the clinical environment.

宿主-噬菌体相互作用和治疗建模。
噬菌体是地球上许多生态过程的驱动因素,有可能被开发成抗生素的替代疗法。噬菌体在其生命周期的各个阶段,从感染开始到释放,都以某种方式与宿主相互作用。更重要的是,为了利用它们的抗菌潜力,在应用噬菌体进行治疗的背景下,了解噬菌体如何与真核环境相互作用至关重要。在本章中,作为革兰氏阳性菌和阴性菌自然生命周期的一部分,噬菌体与宿主相互作用的各种机制被深入讨论。此外,还研究了围绕用于开发噬菌体作为治疗药物的各种模型的文献,以及这些模型如何提高我们对噬菌体-宿主相互作用的理解,以及在临床环境中利用噬菌体进行治疗的当前进展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
5.00
自引率
0.00%
发文量
110
审稿时长
4-8 weeks
期刊介绍: Progress in Molecular Biology and Translational Science (PMBTS) provides in-depth reviews on topics of exceptional scientific importance. If today you read an Article or Letter in Nature or a Research Article or Report in Science reporting findings of exceptional importance, you likely will find comprehensive coverage of that research area in a future PMBTS volume.
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