Non-coding RNA profile for natural killer cell activity

IF 2.3 3区生物学 Q3 BIOCHEMICAL RESEARCH METHODS

Molecular and Cellular Probes Pub Date : 2023-10-08 DOI:10.1016/j.mcp.2023.101935

Soudeh Ghafouri-Fard , Arian Askari , Alireza Zangooie , Hamed Shoorei , Hasan Pourmoshtagh , Mohammad Taheri

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引用次数: 0

Abstract

Natural killer cells (NK cells) are a type of cytotoxic lymphocytes which are involved in innate immunity, alongside with assisting with adaptive immune response. Since they have cytotoxic effects, disruptions in their functionality and development leads to a variety of conditions, whether malignant or non-malignant. The profile and interaction of these non-coding RNAs and NK cells in different conditions is extensively studied, and it is now approved that if dysregulated, non-coding RNAs have detrimental effects on NK cell activity and can contribute to the pathogenesis of diverse disorders. In this review, we aim at a thorough inspection on the role of different non-coding RNAs on the activity and development of NK cells, in a broad spectrum of conditions, including blood-related disorders, viral infections, neurological diseases, gastrointestinal disorders, lung disorders, reproductive system conditions and other types of maladies, alongside with providing insight to the future non-coding RNA-NK cell studies.

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自然杀伤细胞活性的非编码RNA图谱。

自然杀伤细胞（NK细胞）是一种细胞毒性淋巴细胞，参与先天免疫，并协助适应性免疫反应。由于它们具有细胞毒性作用，其功能和发育的破坏会导致各种疾病，无论是恶性还是非恶性。这些非编码RNA和NK细胞在不同条件下的分布和相互作用被广泛研究，现在已经证实，如果失调，非编码RNA会对NK细胞活性产生有害影响，并可能导致多种疾病的发病机制。在这篇综述中，我们旨在彻底检查不同的非编码RNA在各种疾病中对NK细胞活性和发育的作用，包括血液相关疾病、病毒感染、神经系统疾病、胃肠道疾病、肺部疾病、生殖系统疾病和其他类型的疾病，同时为未来的非编码RNA-NK细胞研究提供见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular and Cellular Probes 生物-生化研究方法

CiteScore

6.80

自引率

0.00%

发文量

审稿时长

16 days

期刊介绍： MCP - Advancing biology throughâ€“omics and bioinformatic technologies wants to capture outcomes from the current revolution in molecular technologies and sciences. The journal has broadened its scope and embraces any high quality research papers, reviews and opinions in areas including, but not limited to, molecular biology, cell biology, biochemistry, immunology, physiology, epidemiology, ecology, virology, microbiology, parasitology, genetics, evolutionary biology, genomics (including metagenomics), bioinformatics, proteomics, metabolomics, glycomics, and lipidomics. Submissions with a technology-driven focus on understanding normal biological or disease processes as well as conceptual advances and paradigm shifts are particularly encouraged. The Editors welcome fundamental or applied research areas; pre-submission enquiries about advanced draft manuscripts are welcomed. Top quality research and manuscripts will be fast-tracked.