The Prevalent Cases of Endometrial Carcinoma in Different Life Periods of Women-Clinical and Histopathological Diagnosis.

Current health sciences journal Pub Date : 2023-04-01 Epub Date: 2023-06-30 DOI:10.12865/CHSJ.49.02.151
Hajrullah Latifi, Astrit M Gashi, Drilon Latifi
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Abstract

Abnormal uterine bleeding is a term used to describe any irregular bleeding from the uterus that is not part of a woman's normal menstrual cycle and can happen during different life periods. Abnormal uterine bleeding can have structural etiologies (polyp, adenomyosis, leiomyoma, malignancy) or nonstructural etiologies (coagulopathy, ovulatory dysfunction, and not-classified). The post- and pre-menopausal period requires a detailed investigation to establish the etiology of the bleeding because the chances that the woman has a malignancy are plentiful in this period. The treatment plan is determined based on the underlying cause of the bleeding. The main objective of this paper was to determine the prevalence of endometrial carcinoma in different periods, focusing on the postmenopausal period. This research was a cross-sectional study and included 79 cases of abnormal uterine bleeding in different periods of women's lives. Our study found that abnormal uterine bleeding occurs more frequently during the premenopausal period (59%) and that the causes of irregular bleeding during this period were mainly benign. Our study focused on the postmenopausal period, where we found that 32.9% of irregular uterine bleeding occurs during this period, and the leading causes were malignant pathologies (83.3%), mainly endometrial adenocarcinomas. The average age was 66.7 years. During the study, it was observed that 50% of women with abnormal uterine bleeding due to malignancy were classified as overweight, 25% were obese, and 25% had normal weight. It was confirmed that obesity is a co-factor of malignancy in the postmenopausal period, and the pathophysiological mechanism is well understood now. Our study also found a high number of co-morbidities among women with abnormal uterine bleeding due to malignancy. We came to the conclusion that any abnormal uterine bleeding should be initially investigated in a multidisciplinary manner, an accurate diagnosis should be determined, and then a treatment plan should be established. The treatment strategy should be determined depending on the cause of abnormal bleeding.

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不同生命周期妇女子宫内膜癌的临床和组织病理诊断。
异常子宫出血是一个术语,用于描述子宫中的任何不规则出血,这些出血不是女性正常月经周期的一部分,可能发生在不同的生命周期。异常子宫出血可能有结构性病因(息肉、子宫腺肌病、平滑肌瘤、恶性肿瘤)或非结构性病因(凝血障碍、排卵功能障碍,未分类)。绝经后和绝经前需要进行详细的调查,以确定出血的病因,因为在这个时期,女性患恶性肿瘤的可能性很大。治疗方案是根据出血的根本原因确定的。本文的主要目的是确定子宫内膜癌在不同时期的患病率,重点是绝经后时期。这项研究是一项横断面研究,包括女性生命中不同时期的79例异常子宫出血。我们的研究发现,异常子宫出血在绝经前时期发生得更频繁(59%),而这一时期不规则出血的原因主要是良性的。我们的研究集中在绝经后时期,发现32.9%的不规则子宫出血发生在这一时期,主要原因是恶性病变(83.3%),主要是子宫内膜腺癌。平均年龄66.7岁。在研究过程中,观察到50%因恶性肿瘤导致异常子宫出血的女性被归类为超重,25%为肥胖,25%为正常体重。已证实肥胖是绝经后恶性肿瘤的共同因素,其病理生理机制目前已得到很好的了解。我们的研究还发现,恶性肿瘤导致异常子宫出血的女性中有大量合并症。我们得出的结论是,任何异常子宫出血都应该以多学科的方式进行初步调查,确定准确的诊断,然后制定治疗计划。应根据异常出血的原因确定治疗策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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