Chronic Obstructive Pulmonary Disease Mortality in Bladder Cancer Patients: A SEER-Based Competing Risk Analysis.

IF 1.5 4区医学 Q3 UROLOGY & NEPHROLOGY

Urology Journal Pub Date : 2024-05-06 DOI:10.22037/uj.v20i.7644

Shunde Wang, Chengguo Ge

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引用次数: 0

Abstract

Purpose: This study was designed to evaluate risk of mortality from chronic obstructive pulmonary disease (COPD) in patients with bladder cancer (BC).

Methods and materials: Data on patients diagnosed with BC by pathology between 2000 and 2016 were collected from the Surveillance, Epidemiology, and End Results (SEER) database. Based on reference data from the general population, the standardized mortality rate (SMR) is calculated. Nelson-Aalen cumulative hazard curves were used for assessment of the risk of COPD mortality in BC patients. Multivariable competing risk models were conducted. The proportional hazards assumption was tested using Schoenfeld residuals, which were scaled and plotted over time for each risk factor.

Results: A total of 237,563 BC patients were identified for further analysis from the SEER database, 5,198 of these patients experienced COPD mortality; the overall SMR for COPD mortality in BC patients was 1.58 (95% CI: 1.54-1.63). Age, race, year of diagnosis, histologic type, summary stage, surgery, marital status, college education level, and median household income independently predicted COPD mortality in BC patients.

Conclusions: In comparison to the general population, the risk of COPD mortality is significantly higher in patients with BC. Pre-identification of high-risk groups and respiratory care provisions are important measures to effectively improve survival in this group of patients.

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膀胱癌症患者慢性阻塞性肺病死亡率：基于SEER的竞争风险分析。

目的：本研究旨在评估慢性阻塞性肺病（COPD）患者死于膀胱癌症（BC）的风险。方法和材料：从监测、流行病学和最终结果（SEER）数据库收集2000年至2016年经病理诊断为慢性阻塞性肺疾病（BC）患者的数据。根据普通人群的参考数据，计算标准化死亡率（SMR）。Nelson-Aalen累积危险曲线用于评估BC患者COPD死亡率的风险。进行了多变量竞争风险模型。比例风险假设使用舍恩菲尔德残差进行了测试，该残差随时间对每个风险因素进行了缩放和绘制。结果：SEER数据库中共确定237563名BC患者进行进一步分析，其中5198名患者出现COPD死亡率；BC患者COPD死亡率的总体SMR为1.58（95%CI:1.54-1.63）。年龄、种族、诊断年份、组织学类型、总结阶段、手术、婚姻状况、大学教育水平和家庭收入中位数独立预测BC患者的COPD死亡率。结论：与普通人群相比，慢性阻塞性肺病患者的死亡率明显更高。预先识别高危人群和提供呼吸护理是有效提高这类患者生存率的重要措施。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Urology Journal UROLOGY & NEPHROLOGY-

CiteScore

2.60

自引率

6.70%

发文量

审稿时长

6-12 weeks

期刊介绍： As the official journal of the Urology and Nephrology Research Center (UNRC) and the Iranian Urological Association (IUA), Urology Journal is a comprehensive digest of useful information on modern urology. Emphasis is on practical information that reflects the latest diagnostic and treatment techniques. Our objectives are to provide an exceptional source of current and clinically relevant research in the discipline of urology, to reflect the scientific work and progress of our colleagues, and to present the articles in a logical, timely, and concise format that meets the diverse needs of today’s urologist. Urology Journal publishes manuscripts on urology and kidney transplantation, all of which undergo extensive peer review by recognized authorities in the field prior to their acceptance for publication. Accordingly, original articles, case reports, and letters to editor are encouraged.