Silent brain infarct in migraine: Systematic review and meta-analysis

IF 2.8 4区医学 Q2 CLINICAL NEUROLOGY

Revue neurologique Pub Date : 2024-06-01 DOI:10.1016/j.neurol.2023.05.003

A. Espanol , F. Lerebours , L. Calviere , F. Bonneville , A. Ducros , V. Larrue , C. Gollion

{"title":"Silent brain infarct in migraine: Systematic review and meta-analysis","authors":"A. Espanol , F. Lerebours , L. Calviere , F. Bonneville , A. Ducros , V. Larrue , C. Gollion","doi":"10.1016/j.neurol.2023.05.003","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p><span>While migraine, particularly migraine with aura, is a recognized risk factor for </span>ischemic stroke<span>, the association of migraine with silent brain infarction is a matter of debate, as studies on this topic have yielded conflicting results.</span></p></div><div><h3>Methods</h3><p>A systematic review of the literature was conducted of studies reporting migraine and silent brain infarction, assessed by magnetic resonance imaging, between January 1980 and April 2022, by consulting Medline and Embase databases. Studies with a control group were included in a meta-analysis of population-based studies. An exploratory meta-analysis of both population-based and clinical-based studies was further performed to test the association between migraine with aura and silent brain infarction.</p></div><div><h3>Results</h3><p>A total of 2,408 articles were identified, among which 24 were included in the systematic review and 10 in the meta-analysis. The meta-analysis of population-based studies showed no association of migraine with silent brain infarction (odds ratio (OR)=1.32 [95% CI 0.92;1.90], <em>P</em>    =0.24). However, in the exploratory meta-analysis of population-based and clinical-based studies, migraine with aura was significantly associated with silent brain infarction (OR=1.91 [1.02;3.59], <em>P</em>    =0.05).</p></div><div><h3>Conclusion</h3><p>In this updated systematic review and meta-analysis of population-based studies, migraine and migraine with aura were not associated with silent brain infarction.</p></div>","PeriodicalId":21321,"journal":{"name":"Revue neurologique","volume":"180 6","pages":"Pages 486-493"},"PeriodicalIF":2.8000,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Revue neurologique","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0035378723010111","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background

While migraine, particularly migraine with aura, is a recognized risk factor for ischemic stroke, the association of migraine with silent brain infarction is a matter of debate, as studies on this topic have yielded conflicting results.

Methods

A systematic review of the literature was conducted of studies reporting migraine and silent brain infarction, assessed by magnetic resonance imaging, between January 1980 and April 2022, by consulting Medline and Embase databases. Studies with a control group were included in a meta-analysis of population-based studies. An exploratory meta-analysis of both population-based and clinical-based studies was further performed to test the association between migraine with aura and silent brain infarction.

Results

A total of 2,408 articles were identified, among which 24 were included in the systematic review and 10 in the meta-analysis. The meta-analysis of population-based studies showed no association of migraine with silent brain infarction (odds ratio (OR) = 1.32 [95% CI 0.92;1.90], P = 0.13) and migraine with aura with silent brain infarction (OR = 1.56 [0.74;3.30], P = 0.24). However, in the exploratory meta-analysis of population-based and clinical-based studies, migraine with aura was significantly associated with silent brain infarction (OR = 1.91 [1.02;3.59], P = 0.04) and to silent cerebellar infarcts (OR = 2.57 [1.01;6.56], P = 0.05).

Conclusion

In this updated systematic review and meta-analysis of population-based studies, migraine and migraine with aura were not associated with silent brain infarction.

Abstract Image

查看原文本刊更多论文

偏头痛的无症状脑梗死：系统综述和荟萃分析。

背景：虽然偏头痛，特别是先兆偏头痛，是缺血性中风的一个公认的风险因素，但偏头痛与无症状脑梗死的关系是一个有争议的问题，因为关于这一主题的研究得出了相互矛盾的结果。方法：通过查阅Medline和Embase数据库，对1980年1月至2022年4月期间通过磁共振成像评估的偏头痛和无症状脑梗死研究的文献进行系统回顾。对照组的研究被纳入一项基于人群的研究的荟萃分析。对基于人群和临床的研究进行了一项探索性荟萃分析，以测试先兆偏头痛与无症状脑梗死之间的关系。结果：共鉴定出2408篇文章，其中24篇纳入系统综述，10篇纳入荟萃分析。基于人群研究的荟萃分析显示，偏头痛与无症状性脑梗死（比值比（OR）=1.32[95%CI 0.92；1.90]，P=0.013）和先兆偏头痛与无障碍性脑梗死（OR=1.56[0.74；3.30]，P=0.024）之间没有关联。然而，在基于人群和临床研究的探索性荟萃分析中，先兆偏头痛与无症状脑梗死（OR=1.91[1.02；3.59]，P=0.04）和无症状小脑梗死（OR=2.57[1.01；6.56]，P=0.05）显著相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Revue neurologique 医学-临床神经学

CiteScore

4.80

自引率

0.00%

发文量

598

审稿时长

55 days

期刊介绍： The first issue of the Revue Neurologique, featuring an original article by Jean-Martin Charcot, was published on February 28th, 1893. Six years later, the French Society of Neurology (SFN) adopted this journal as its official publication in the year of its foundation, 1899. The Revue Neurologique was published throughout the 20th century without interruption and is indexed in all international databases (including Current Contents, Pubmed, Scopus). Ten annual issues provide original peer-reviewed clinical and research articles, and review articles giving up-to-date insights in all areas of neurology. The Revue Neurologique also publishes guidelines and recommendations. The Revue Neurologique publishes original articles, brief reports, general reviews, editorials, and letters to the editor as well as correspondence concerning articles previously published in the journal in the correspondence column.