The Impacts of Fecal Microbiota Transplantation from Same Sex on the Symptoms of Ulcerative Colitis Patients.

Polish journal of microbiology Pub Date : 2023-09-20 eCollection Date: 2023-09-01 DOI:10.33073/pjm-2023-025
Shu Shang, Jian Zhu, Xi Liu, Wei Wang, Tingting Dai, Li Wang, Baojun Li
{"title":"The Impacts of Fecal Microbiota Transplantation from Same Sex on the Symptoms of Ulcerative Colitis Patients.","authors":"Shu Shang,&nbsp;Jian Zhu,&nbsp;Xi Liu,&nbsp;Wei Wang,&nbsp;Tingting Dai,&nbsp;Li Wang,&nbsp;Baojun Li","doi":"10.33073/pjm-2023-025","DOIUrl":null,"url":null,"abstract":"<p><p>We aimed to compare the clinical efficacy of fecal microbiota transplantation (FMT) from the same sex on ulcerative colitis (UC) patients. A total of 272 UC patients were selected in the prospective clinical study, which incorporated four distinct groups, each comprising male and female patients, who were either receiving FMT or placebo, respectively. FMT was performed by sending the gut microbiota of healthy female or male adolescents to the same gender patients via gastroscope three times (one time/three weeks), and a placebo was used with an equal volume of saline. Abdominal pain, diarrhea, thick bloody stool, intestinal mucosal lesion, and Mayo scores were measured. Self-rating anxiety scale (SAS) and self-rating depression scale (SDS) were evaluated. The changes of intestinal flora were detected by the 16S rRNA sequencing. FMT reduced the scores of diarrhea, abdominal pain, mucosal lesion, and Mayo, SAS, and SDS in UC patients compared to the placebo group (<i>p</i> < 0.05). Clostridiales and <i>Desulfovibrionaceae</i> were dominant in gut microbiota from male patients and were reduced after FMT. Meanwhile, the abundance of <i>Prevotella</i>, <i>Lactobacillus</i>, and <i>Bifidobacterium</i> was increased in the male group. Female patients had a higher abundance of <i>Escherichia-Shigella</i>, <i>Desulfovibrionaceae</i>, and <i>Staphylococcaceae</i> before FMT, and it was reduced after FMT. Meanwhile, the abundance of <i>Porphyromonadaceae</i>, <i>Prevotella</i>, <i>Lactobacillus</i>, and <i>Bifidobacterium</i> was increased in the female group. There were no significant changes for the species in the corresponding placebo groups. FMT improved the UC symptoms of male and female patients, which may be associated with different gut microbiota changes.</p>","PeriodicalId":94173,"journal":{"name":"Polish journal of microbiology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/73/9c/pjm-72-3-pjm-2023-025.PMC10508974.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Polish journal of microbiology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.33073/pjm-2023-025","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/9/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

We aimed to compare the clinical efficacy of fecal microbiota transplantation (FMT) from the same sex on ulcerative colitis (UC) patients. A total of 272 UC patients were selected in the prospective clinical study, which incorporated four distinct groups, each comprising male and female patients, who were either receiving FMT or placebo, respectively. FMT was performed by sending the gut microbiota of healthy female or male adolescents to the same gender patients via gastroscope three times (one time/three weeks), and a placebo was used with an equal volume of saline. Abdominal pain, diarrhea, thick bloody stool, intestinal mucosal lesion, and Mayo scores were measured. Self-rating anxiety scale (SAS) and self-rating depression scale (SDS) were evaluated. The changes of intestinal flora were detected by the 16S rRNA sequencing. FMT reduced the scores of diarrhea, abdominal pain, mucosal lesion, and Mayo, SAS, and SDS in UC patients compared to the placebo group (p < 0.05). Clostridiales and Desulfovibrionaceae were dominant in gut microbiota from male patients and were reduced after FMT. Meanwhile, the abundance of Prevotella, Lactobacillus, and Bifidobacterium was increased in the male group. Female patients had a higher abundance of Escherichia-Shigella, Desulfovibrionaceae, and Staphylococcaceae before FMT, and it was reduced after FMT. Meanwhile, the abundance of Porphyromonadaceae, Prevotella, Lactobacillus, and Bifidobacterium was increased in the female group. There were no significant changes for the species in the corresponding placebo groups. FMT improved the UC symptoms of male and female patients, which may be associated with different gut microbiota changes.

同性粪便微生物群移植对溃疡性结肠炎患者症状的影响。
我们旨在比较同性粪便微生物群移植(FMT)对溃疡性结肠炎(UC)患者的临床疗效。在这项前瞻性临床研究中,共选择了272名UC患者,该研究包括四个不同的组,每个组包括男性和女性患者,他们分别接受FMT或安慰剂治疗。FMT通过胃镜将健康女性或男性青少年的肠道微生物群发送给同性别患者三次(一次/3周),并使用等量生理盐水的安慰剂。测量腹痛、腹泻、浓血便、肠粘膜损伤和Mayo评分。评定焦虑自评量表(SAS)和抑郁自评量量表(SDS)。通过16S rRNA测序检测肠道菌群的变化。与安慰剂组相比,FMT降低了UC患者腹泻、腹痛、粘膜病变以及Mayo、SAS和SDS的评分(p<0.05)。梭状芽孢杆菌和脱硫弧菌科在男性患者的肠道微生物群中占主导地位,FMT后降低。同时,男性组中普雷沃氏菌、乳酸杆菌和双歧杆菌的丰度增加。女性患者在FMT前大肠杆菌志贺菌、脱硫弧菌科和葡萄球菌科的丰度较高,FMT后丰度降低。同时,女性组中卟啉单胞菌科、普雷沃氏菌、乳酸杆菌和双歧杆菌的丰度增加。在相应的安慰剂组中,物种没有显著变化。FMT改善了男性和女性患者的UC症状,这可能与不同的肠道微生物群变化有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信