Could ultrasound and muscle elastography be associated with clinical assessment, laboratory and nailfold capillaroscopy in juvenile dermatomyositis patients?

IF 2 4区 医学 Q3 RHEUMATOLOGY
Renata Lopes Francisco de Andrade, José Alexandre Mendonça, Daniela Petry Piotto, Julio Brandão Guimarães, Maria Teresa Terreri
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引用次数: 0

Abstract

Background: Juvenile Dermatomyositis (JDM) is the most common idiopathic inflammatory myopathy in children. Imaging exams are useful for muscle assessment, with ultrasonography (US) being a promising tool in detecting disease activity and tissue damage. There are few studies about muscle elastography.

Objectives: Our aim was to associate clinical, laboratory, and nailfold capillaroscopy (NC) assessments with US in JDM patients; and to compare the findings of US and Strain Elastography (SE) from patients and healthy controls.

Methods: An analytic cross-sectional study was performed with JDM patients and healthy controls. Patients underwent clinical exam to access muscle strength and completed questionnaires about global assessment of the disease and functional capacity. Patients were submitted to NC and measurement of muscle enzymes. All subjects underwent US assessment, using gray scale, Power Doppler (PD), and SE.

Results: Twenty-two JDM patients and fourteen controls, aged between 5 and 21 years, matched for age and sex were assessed. In qualitative and semi-quantitative gray scale, we observed a higher frequency of alterations in patients (p < 0.001), while in PD, there was a higher frequency of positivity in patients' deltoids and anterior tibialis (p < 0.001). Active disease was associated with an important change in the semi-quantitative gray scale in deltoids (p = 0.007), biceps brachii (p = 0.001) and quadriceps femoris (p = 0.005). The SE demonstrated a high negative predictive value of 87.2.

Conclusion: US was able, through gray scale, to differentiate JDM patients from controls, while PD achieved such differentiation only for deltoids and anterior tibialis. The semi-quantitative gray scale showed disease activity in proximal muscles. SE was not able to differentiate patients from controls.

超声和肌肉弹性成像是否与青少年皮肌炎患者的临床评估、实验室检查和甲襞乳头镜检查有关?
背景:青少年皮肌炎(JDM)是儿童最常见的特发性炎症性肌病。影像学检查对肌肉评估很有用,超声(US)是检测疾病活动和组织损伤的一种很有前途的工具。关于肌肉弹性成像的研究很少。目的:我们的目的是将临床、实验室和甲襞乳头镜检查(NC)评估与JDM患者的US联系起来;并比较来自患者和健康对照的US和应变弹性成像(SE)的结果。方法:对JDM患者和健康对照组进行横断面分析研究。患者接受了临床检查以获得肌肉力量,并完成了关于疾病和功能能力全球评估的问卷调查。患者接受NC和肌肉酶测定。所有受试者都接受了使用灰度、功率多普勒(PD)和SE的US评估。结果:评估了22名JDM患者和14名年龄在5至21岁之间、年龄和性别匹配的对照组。在定性和半定量灰度中,我们观察到患者的改变频率更高(p 结论:US能够通过灰度区分JDM患者和对照组,而PD仅对三角肌和胫骨前肌实现了这种区分。半定量灰度显示近端肌肉的疾病活动。SE无法区分患者和对照组。
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来源期刊
Advances in Rheumatology
Advances in Rheumatology Medicine-Rheumatology
CiteScore
4.00
自引率
4.30%
发文量
41
审稿时长
53 weeks
期刊介绍: Formerly named Revista Brasileira de Reumatologia, the journal is celebrating its 60th year of publication. Advances in Rheumatology is an international, open access journal publishing pre-clinical, translational and clinical studies on all aspects of paediatric and adult rheumatic diseases, including degenerative, inflammatory and autoimmune conditions. The journal is the official publication of the Brazilian Society of Rheumatology and welcomes original research (including systematic reviews and meta-analyses), literature reviews, guidelines and letters arising from published material.
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