Synthetic phage and its application in phage therapy.

3区 生物学 Q2 Biochemistry, Genetics and Molecular Biology
Ajay Kumar, Anuj Yadav
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引用次数: 0

Abstract

Synthetic phage analysis has been implemented in progressive various areas of biology, such as genetics, molecular biology, and synthetic biology. Many phage-derived technologies have been altered for developing gene circuits to program biological systems. Due to their extremely potent potency, phages also provide greater medical availability against bacterial agents and bacterial diagnostic agents. Its host specificity and our growing ability to manipulate, them further expand its possibility. New Phages also genetically redesign programmable biomaterials with highly tunable properties. Moreover, new phages are central to powerful directed evolution platforms. It is used to enhance existing biological, functions to create new phages. In other sites, the mining of antibiotics, and the emergence and dissemination of more than one type of drug-resistant microbe, a human health concerns. The major point in controlling and treating microbial infections. At present, genetic modifications and biochemical treatments are used to modify phages. Among these, genetic engineering involves the identification of defective proteins, modification of host bodies, recognized receptors, and disruption of bacterial phage resistance signaling gateways.

合成噬菌体及其在噬菌体治疗中的应用。
合成噬菌体分析已经在生物学的各个领域得到了应用,如遗传学、分子生物学和合成生物学。许多噬菌体衍生的技术已经被改变,用于开发基因电路来编程生物系统。由于其极强的效力,噬菌体还提供了更大的抗细菌制剂和细菌诊断剂的医疗可用性。它的宿主特异性和我们日益增长的操纵能力,进一步扩大了它的可能性。New Phages还从基因上重新设计了具有高度可调特性的可编程生物材料。此外,新的噬菌体是强大的定向进化平台的核心。它被用来增强现有的生物学功能,创造新的噬菌体。在其他地方,抗生素的开采,以及一种以上耐药微生物的出现和传播,都是人类健康问题。控制和治疗微生物感染的要点。目前,基因修饰和生化处理被用于修饰噬菌体。其中,基因工程涉及缺陷蛋白的鉴定、宿主体的修饰、公认的受体以及细菌噬菌体抗性信号通路的破坏。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
5.00
自引率
0.00%
发文量
110
审稿时长
4-8 weeks
期刊介绍: Progress in Molecular Biology and Translational Science (PMBTS) provides in-depth reviews on topics of exceptional scientific importance. If today you read an Article or Letter in Nature or a Research Article or Report in Science reporting findings of exceptional importance, you likely will find comprehensive coverage of that research area in a future PMBTS volume.
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