A single-centre report of acute pyelonephritis in a patient after kidney transplantation - analyses of risk factors.

IF 1.5 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL
Igor Gala, Tatiana Baltesova, Stefan Hulik, Rastislav Kalanin, David Adandedjan, Jana Katuchova, Luboslav Bena
{"title":"A single-centre report of acute pyelonephritis in a patient after kidney transplantation - analyses of risk factors.","authors":"Igor Gala,&nbsp;Tatiana Baltesova,&nbsp;Stefan Hulik,&nbsp;Rastislav Kalanin,&nbsp;David Adandedjan,&nbsp;Jana Katuchova,&nbsp;Luboslav Bena","doi":"10.4149/BLL_2023_114","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Urinary tract infections (UTI) are the most common infectious complications after kidney transplantation (KTx) with highest incidence in the first three months of transplantation. UTI in transplant recipients increase morbidity and mortality, risk of graft failure and incidence of acute rejection episodes. According to published data, urinary tract infections significantly affect graft survival. The aim of our study was to identify possible risk factors for the development of UTI.</p><p><strong>Material and methods: </strong>We retrospectively analyzed a cohort of patients who received kidney transplantation between January 2014 and December 2016 in the Transplant Center of Louis Pasteur University Hospital in Košice. One hundred and fifty-three patients after kidney transplantation were included in the study.</p><p><strong>Results: </strong>A total of 47 Caucasian patients (30%) developed UTI, namely - acute pyelonephritis after KTx. We identified independent risk factors associated with UTI such as female gender OR (7.98, 95% CI 2.88-22.12, p < 0.001), diabetes mellitus (OR 5.26, 95% CI 2.01-13.74, p = 0.001; 95% CI 4.57-53.82, p < 0.001) urologic complication (OR 15.68, 95% CI 4.57-53.82; p < 0.001) and acute rejection episode (OR 3.15, 95% CI 1.13-8.76, p = 0.027). The most common microbiological agent was Escherichia coli.</p><p><strong>Conclusion: </strong>We identified the aforementioned risk factors of urinary tract infections in the files of our patients. Statistically, the most significant risk factors are the female gender, and presence of urological complications. The urological complications and BMI of the patients are considered modifiable factors. Based on our analysis, we confirmed a significantly higher number of ACR patients who overcame infection which is in accordance with the published data on association of UTI with the development of acute cellular rejection (ACR) (Tab. 2, Fig. 1, Ref. 15).</p>","PeriodicalId":55328,"journal":{"name":"Bratislava Medical Journal-Bratislavske Lekarske Listy","volume":null,"pages":null},"PeriodicalIF":1.5000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bratislava Medical Journal-Bratislavske Lekarske Listy","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.4149/BLL_2023_114","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
引用次数: 0

Abstract

Background: Urinary tract infections (UTI) are the most common infectious complications after kidney transplantation (KTx) with highest incidence in the first three months of transplantation. UTI in transplant recipients increase morbidity and mortality, risk of graft failure and incidence of acute rejection episodes. According to published data, urinary tract infections significantly affect graft survival. The aim of our study was to identify possible risk factors for the development of UTI.

Material and methods: We retrospectively analyzed a cohort of patients who received kidney transplantation between January 2014 and December 2016 in the Transplant Center of Louis Pasteur University Hospital in Košice. One hundred and fifty-three patients after kidney transplantation were included in the study.

Results: A total of 47 Caucasian patients (30%) developed UTI, namely - acute pyelonephritis after KTx. We identified independent risk factors associated with UTI such as female gender OR (7.98, 95% CI 2.88-22.12, p < 0.001), diabetes mellitus (OR 5.26, 95% CI 2.01-13.74, p = 0.001; 95% CI 4.57-53.82, p < 0.001) urologic complication (OR 15.68, 95% CI 4.57-53.82; p < 0.001) and acute rejection episode (OR 3.15, 95% CI 1.13-8.76, p = 0.027). The most common microbiological agent was Escherichia coli.

Conclusion: We identified the aforementioned risk factors of urinary tract infections in the files of our patients. Statistically, the most significant risk factors are the female gender, and presence of urological complications. The urological complications and BMI of the patients are considered modifiable factors. Based on our analysis, we confirmed a significantly higher number of ACR patients who overcame infection which is in accordance with the published data on association of UTI with the development of acute cellular rejection (ACR) (Tab. 2, Fig. 1, Ref. 15).

一例肾移植患者急性肾盂肾炎的单中心报告——危险因素分析。
背景:尿路感染(UTI)是肾移植(KTx)后最常见的感染性并发症,在移植的前三个月发病率最高。移植受者尿路感染会增加发病率和死亡率、移植物衰竭风险以及急性排斥反应的发生率。根据已发表的数据,尿路感染显著影响移植物的存活率。我们研究的目的是确定UTI发展的可能风险因素。材料和方法:我们回顾性分析了2014年1月至2016年12月在科希策Louis Pasteur大学医院移植中心接受肾移植的患者队列。153名肾移植后的患者被纳入研究。结果:共有47名高加索患者(30%)在KTx术后发生尿路感染,即急性肾盂肾炎。我们确定了与尿路感染相关的独立风险因素,如女性OR(7.98,95%CI 2.88-22.12,p<0.001),糖尿病(OR 5.26,95%CI 2.01-13.74,p=0.001;95%CI 4.57-53.82,p<0.001)泌尿系统并发症(OR 15.68,95%CI 4.57-13.82,p<001)和急性排斥反应发作(OR 3.15,95%CI 1.13-8.76,p=0.027)。最常见的微生物病原体是大肠杆菌。结论:我们在患者档案中发现了上述尿路感染的危险因素。从统计数据来看,最重要的风险因素是女性和泌尿系统并发症的存在。泌尿系统并发症和患者的BMI被认为是可改变的因素。根据我们的分析,我们证实了克服感染的ACR患者人数显著增加,这与已发表的UTI与急性细胞排斥反应(ACR)发展相关的数据一致(表2,图1,参考文献15)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
CiteScore
2.60
自引率
0.00%
发文量
185
审稿时长
3-8 weeks
期刊介绍: The international biomedical journal - Bratislava Medical Journal – Bratislavske lekarske listy (Bratisl Lek Listy/Bratisl Med J) publishes peer-reviewed articles on all aspects of biomedical sciences, including experimental investigations with clear clinical relevance, original clinical studies and review articles.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信