Impact of Molecular Status on Cytoreductive Surgery for Peritoneal Metastases from Colorectal Cancer.

IF 1.2 4区医学 Q4 GASTROENTEROLOGY & HEPATOLOGY

Clinics in Colon and Rectal Surgery Pub Date : 2023-04-16 eCollection Date: 2023-11-01 DOI:10.1055/s-0043-1767705

Yun Zhong, Keli Yang, Xiusen Qin, Rui Luo, Hui Wang

{"title":"Impact of Molecular Status on Cytoreductive Surgery for Peritoneal Metastases from Colorectal Cancer.","authors":"Yun Zhong, Keli Yang, Xiusen Qin, Rui Luo, Hui Wang","doi":"10.1055/s-0043-1767705","DOIUrl":null,"url":null,"abstract":"<p><p>Colorectal cancer peritoneal metastases (CRC-PM) are present in 5 to 15% of instances of CRC, and the overall survival (OS) of patients with CRC-PM is much lower than that of patients with other isolated metastatic locations. In recent years, the introduction of cytoreductive surgery (CRS) in conjunction with hyperthermic intraperitoneal chemotherapy has resulted in a significant improvement in CRC-PM patients' OS. Despite this, a significant proportion of CRS patients continue to suffer complications of grades III to V or even die during the perioperative period. Early diagnosis, optimization of patient selection criteria, and refining of individualized combination therapy are necessary for these patients. In this review, we evaluate studies examining the relationship between molecular status and CRS in CRC-PM. Our objective is to gain a comprehensive understanding of how the altered molecular status of CRC-PM impacts CRS, which could increase the likelihood of tailored therapy in the future.</p>","PeriodicalId":48754,"journal":{"name":"Clinics in Colon and Rectal Surgery","volume":"36 6","pages":"415-422"},"PeriodicalIF":1.2000,"publicationDate":"2023-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10547537/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinics in Colon and Rectal Surgery","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1055/s-0043-1767705","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/11/1 0:00:00","PubModel":"eCollection","JCR":"Q4","JCRName":"GASTROENTEROLOGY & HEPATOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Colorectal cancer peritoneal metastases (CRC-PM) are present in 5 to 15% of instances of CRC, and the overall survival (OS) of patients with CRC-PM is much lower than that of patients with other isolated metastatic locations. In recent years, the introduction of cytoreductive surgery (CRS) in conjunction with hyperthermic intraperitoneal chemotherapy has resulted in a significant improvement in CRC-PM patients' OS. Despite this, a significant proportion of CRS patients continue to suffer complications of grades III to V or even die during the perioperative period. Early diagnosis, optimization of patient selection criteria, and refining of individualized combination therapy are necessary for these patients. In this review, we evaluate studies examining the relationship between molecular status and CRS in CRC-PM. Our objective is to gain a comprehensive understanding of how the altered molecular status of CRC-PM impacts CRS, which could increase the likelihood of tailored therapy in the future.

查看原文本刊更多论文

分子状态对癌症腹膜转移细胞减灭术的影响。

结直肠癌癌症腹膜转移（CRC-PM）存在于5%至15%的CRC病例中，CRC-PM患者的总生存率（OS）远低于其他孤立转移部位的患者。近年来，细胞减灭术（CRS）结合腹腔内高温化疗的引入显著改善了CRC-PM患者的OS。尽管如此，仍有相当一部分CRS患者在围手术期继续出现III至V级并发症，甚至死亡。对这些患者来说，早期诊断、优化患者选择标准和完善个体化联合治疗是必要的。在这篇综述中，我们评估了CRC-PM中分子状态与CRS之间关系的研究。我们的目标是全面了解CRC-PM分子状态的改变如何影响CRS，这可能会增加未来量身定制治疗的可能性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Clinics in Colon and Rectal Surgery GASTROENTEROLOGY & HEPATOLOGYSURGERY-SURGERY

CiteScore

2.60

自引率

7.10%

发文量

期刊介绍： Clinics in Colon and Rectal Surgery is a review journal that publishes topic-specific issues on diseases of the small bowel, colon, rectum, and anus. Designed for clinicians, researchers, and educators involved with diseases of the intestinal tract, the journal covers a broad spectrum of basic information, controversial clinical issues, and established and innovative diagnostic techniques. Issue topics comprehensively cover the entire specialty over a 3-4 year period, allowing the articles to serve as study material for educational programs and certifying examinations. The inclusion of research and clinical material also allows physicians to remain knowledgeable of current advances in the specialty.