Phage therapy for Acinetobacter baumannii infection.

3区 生物学 Q2 Biochemistry, Genetics and Molecular Biology
Ramneet Kaur, Dibita Mandal, Ajay Kumar
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引用次数: 1

Abstract

Acinetobacter is a gram-negative nosocomial pathogenic bacteria. The contributing factor for the pathogenicity of Acinetobacter is severe due to its property of antibacterial drug resistance. Often antibiotic treatment is used to treat bacterial infection, however due to the resistance of a broad range of antibiotics by Acinetobacter the treatment viability of this bacterial species seems to be reduced. To combat this diverse treatment options are being incorporated with phage therapy being an effective choice due to its intrinsic property to infect bacteria. In this chapter the various phage therapy used in recent times has been elaborated on. The phage therapy is considered to be in response to Carbapenem resistance. The various mode of phage propagation has been mentioned in this chapter along with the type of resistance conferred to the administered therapy. The chapter deals with the advances observed due to therapy of Acibel004, Acibel007, vB-GEC_Ab-M-G7, ZZ1 and Bacteriophage p54 containing Endolysin LysAB54 bacteriophages have been elucidated.

噬菌体治疗鲍曼不动杆菌感染。
不动杆菌是一种革兰氏阴性的医院病原菌。不动杆菌具有抗菌耐药性,是致病性的重要因素。抗生素治疗通常用于治疗细菌感染,然而,由于不动杆菌对多种抗生素的耐药性,这种细菌的治疗可行性似乎降低了。为了对抗这种多样的治疗选择,噬菌体疗法是一种有效的选择,因为它具有感染细菌的内在特性。本章详细介绍了近年来使用的各种噬菌体疗法。噬菌体疗法被认为是对碳青霉烯耐药性的反应。本章已经提到了噬菌体繁殖的各种模式,以及给予治疗的耐药性类型。本章介绍了Acibel004、Acibel007、vB-GEC_Ab-M-G7、ZZ1和含有溶血素LysAB54的噬菌体p54的治疗进展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
5.00
自引率
0.00%
发文量
110
审稿时长
4-8 weeks
期刊介绍: Progress in Molecular Biology and Translational Science (PMBTS) provides in-depth reviews on topics of exceptional scientific importance. If today you read an Article or Letter in Nature or a Research Article or Report in Science reporting findings of exceptional importance, you likely will find comprehensive coverage of that research area in a future PMBTS volume.
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