Phages for treatment of Klebsiella pneumoniae infections.

3区 生物学 Q2 Biochemistry, Genetics and Molecular Biology
Bishoy Maher Zaki, Assmaa H Hussein, Toka A Hakim, Mohamed S Fayez, Ayman El-Shibiny
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引用次数: 0

Abstract

Klebsiella pneumoniae is an opportunistic pathogen involved in both hospital- and community-acquired infections. K. pneumoniae is associated with various infections, including pneumonia, septicemia, meningitis, urinary tract infection, and surgical wound infection. K. pneumoniae possesses serious virulence, biofilm formation ability, and severe resistance to many antibiotics especially hospital-acquired strains, due to excessive use in healthcare systems. This limits the available effective antibiotics that can be used for patients suffering from K. pneumoniae infections; therefore, alternative treatments are urgently needed. Bacteriophages (for short, phages) are prokaryotic viruses capable of infecting, replicating, and then lysing (lytic phages) the bacterial host. Phage therapy exhibited great potential for treating multidrug-resistant bacterial infections comprising K. pneumoniae. Hence, this chapter emphasizes and summarizes the research articles in the PubMed database from 1948 until the 15th of December 2022, addressing phage therapy against K. pneumoniae. The chapter provides an overview of K. pneumoniae phages covering different aspects, including phage isolation, different morphotypes of isolated phages, in vitro characterization, anti-biofilm activity, various therapeutic forms, in vivo research and clinical studies.

用于治疗肺炎克雷伯菌感染的噬菌体。
肺炎克雷伯菌是一种机会性病原体,涉及医院和社区获得性感染。肺炎克雷伯菌与各种感染有关,包括肺炎、败血症、脑膜炎、尿路感染和外科伤口感染。由于在医疗系统中过度使用,肺炎克雷伯菌具有严重的毒力、生物膜形成能力和对许多抗生素的严重耐药性,尤其是医院获得的菌株。这限制了可用于肺炎克雷伯菌感染患者的有效抗生素;因此,迫切需要替代疗法。噬菌体(简称噬菌体)是一种能够感染、复制并裂解(裂解噬菌体)细菌宿主的原核病毒。噬菌体疗法在治疗包括肺炎克雷伯菌在内的耐多药细菌感染方面显示出巨大潜力。因此,本章强调并总结了PubMed数据库中从1948年到2022年12月15日的研究文章,涉及针对肺炎克雷伯菌的噬菌体治疗。本章概述了肺炎克雷伯菌噬菌体的不同方面,包括噬菌体分离、分离噬菌体的不同形态类型、体外表征、抗生物膜活性、各种治疗形式、体内研究和临床研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
5.00
自引率
0.00%
发文量
110
审稿时长
4-8 weeks
期刊介绍: Progress in Molecular Biology and Translational Science (PMBTS) provides in-depth reviews on topics of exceptional scientific importance. If today you read an Article or Letter in Nature or a Research Article or Report in Science reporting findings of exceptional importance, you likely will find comprehensive coverage of that research area in a future PMBTS volume.
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