Predictive Models of Muscle Strength in Older People with Type 2 Diabetes Mellitus.

IF 3.5 3区医学 Q2 GERIATRICS & GERONTOLOGY

Clinical Interventions in Aging Pub Date : 2023-09-14 eCollection Date: 2023-01-01 DOI:10.2147/CIA.S414620

Mateus Medeiros Leite, Ivo Vieira de Sousa Neto, Maurílio Tiradentes Dutra, Silvana Schwerz Funghetto, Alessandro de Oliveira Silva, Izabel Cristina Rodrigues da Silva, Luciano Ramos de Lima, Marina Morato Stival

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Abstract

Purpose: To propose predictive models for absolute muscle strength (AMS) of elderly people with type 2 Diabetes Mellitus (DM2) in primary health care.

Patients and methods: The cross-sectional study was conducted with 138 elderly diabetics. The AMS was measured by a JAMAR^® hydraulic handgrip dynamometer, determined by the sum of both hands. The following indices were evaluated: waist-to-height ratio (WHtR), body mass index (BMI), Lipid Accumulation Product (LAP), Triglyceride/High Density Lipoprotein (TG/HDL) ratio and platelet/lymphocyte ratio (PLR). Multiple linear regression was used in the statistical analysis.

Results: The final regression model indicated 66.4% (R²=0.66) of the variation in AMS. WHtR decreased AMS by 41.1% (β = -0.19; t = -3.70; p < 0.001), while PLR by 11.3% (β = -0.12; t = -2.36; p = 0.020). Male sex increased AMS by 10.6% (β = 0.32; t = 4.16; p < 0.001), and lean mass (LM) by 0.89% (β = 0.46; t = 6.03; p < 0.001).

Conclusion: WHtR and PLR predicted a decrease, while male sex and LM predicted an increase in AMS. It is suggested that these markers be used as screening measures for variation in AMS in older adults with DM2. These results have relevant practical application in primary health care since the markers are easy to use.

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老年2型糖尿病患者肌肉力量的预测模型。

目的：提出初级保健中老年2型糖尿病（DM2）患者绝对肌力（AMS）的预测模型。患者和方法：对138名老年糖尿病患者进行横断面研究。AMS通过JAMAR®液压手柄测功机测量，由双手之和确定。评估了以下指标：腰高比（WHtR）、体重指数（BMI）、脂质蓄积产物（LAP）、甘油三酯/高密度脂蛋白（TG/HDL）比率和血小板/淋巴细胞比率（PLR）。统计分析采用多元线性回归。结果：最终回归模型显示AMS的变化率为66.4%（R²=0.66）。WHtR使AMS降低41.1%（β=0.19；t=-3.70；p＜0.001），而PLR降低11.3%（β=0.12；t=-2.36；p＝0.020）。男性使AMS增加10.6%（β0.32；t=4.16；p＜001），瘦体重（LM）增加0.89%（β0.46；t=6.03；p＜0.01）。结论：WHtR和PLR预测AMS降低，而男性和LM预测AMS增加。建议将这些标记物用作患有DM2的老年人AMS变异的筛查措施。这些结果在初级卫生保健中具有相关的实际应用，因为标记物易于使用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Interventions in Aging GERIATRICS & GERONTOLOGY-

CiteScore

6.80

自引率

2.80%

发文量

193

审稿时长

6-12 weeks

期刊介绍： Clinical Interventions in Aging, is an online, peer reviewed, open access journal focusing on concise rapid reporting of original research and reviews in aging. Special attention will be given to papers reporting on actual or potential clinical applications leading to improved prevention or treatment of disease or a greater understanding of pathological processes that result from maladaptive changes in the body associated with aging. This journal is directed at a wide array of scientists, engineers, pharmacists, pharmacologists and clinical specialists wishing to maintain an up to date knowledge of this exciting and emerging field.