Cytomorphological findings in drug defaulters of tuberculous lymphadenitis.

IF 2.5 4区医学 Q2 PATHOLOGY

Cytojournal Pub Date : 2023-09-04 eCollection Date: 2023-01-01 DOI:10.25259/Cytojournal_16_2023

Aarti Kumari, Sana Ahuja, Sachin Bajaj, Sufian Zaheer, Vinod Chaitanya, Yatish Agarwal, Ratan Gupta, Sunil Ranga

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引用次数: 0

Abstract

Objectives: Tuberculosis (TB) is an important health problem specially in the developing countries. Although effective chemotherapy is available, compliance of patient is a major challenge. The aim of this study was to describe cytomorphological features of drug defaulters on lymph node on fine-needle aspiration cytology (FNAC) and compare it with newly diagnosed cases.

Material and methods: A cross-sectional study was done for a period of 18 months, in which all patients having tuberculous lymphadenitis were included after taking detailed history regarding previous anti-TB drug intake. Cytomorphological findings in drug defaulters were evaluated and compared with newly diagnosed cases.

Results: There were a total of 150 cases with 120 newly diagnosed and 30 drug defaulters. Splintered epithelioid cell granuloma was seen in 40% of drug defaulters, while it was absent in case of newly diagnosed cases (P < 0.0001). Well-formed epithelioid cell granuloma was most commonly seen in newly diagnosed cases (65.83%) followed by poorly formed granuloma (26.67%). Another significant finding was distribution of eosinophils which were significantly high in case of drug defaulters (56.67%) (P < 0.0001).

Conclusion: Cytomorphological findings can help in identification of the drug defaulters on FNAC and thus plan further line of treatment.

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结核性淋巴结炎药物滥用者的细胞形态学表现。

目的：结核病是一个重要的健康问题，特别是在发展中国家。尽管可以进行有效的化疗，但患者的依从性是一个重大挑战。本研究的目的是在细针抽吸细胞学（FNAC）上描述药物拖欠者在淋巴结上的细胞形态学特征，并将其与新诊断的病例进行比较。材料和方法：进行了一项为期18个月的横断面研究，所有患有结核性淋巴结炎的患者在详细记录了既往抗结核药物摄入的病史后都被纳入其中。对药物滥用者的细胞形态学结果进行评估，并与新诊断病例进行比较。结果：共有150例病例，其中120例为新确诊病例，30例为吸毒者。40%的吸毒者可见分裂上皮样细胞肉芽肿，而在新诊断的病例中则没有（P＜0.0001）。良好形成的上皮样细胞肉芽肿在新诊断病例中最常见（65.83%），其次是不良形成的肉芽肿（26.67%）。另一个重要的发现是嗜酸性粒细胞的分布，在药物拖欠者中明显较高（56.67%）（P＜0.001）。结论：细胞形态学检查有助于确定FNAC上的药物违规者，从而计划进一步的治疗路线。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cytojournal PATHOLOGY-

CiteScore

2.20

自引率

42.10%

发文量

审稿时长

>12 weeks

期刊介绍： The CytoJournal is an open-access peer-reviewed journal committed to publishing high-quality articles in the field of Diagnostic Cytopathology including Molecular aspects. The journal is owned by the Cytopathology Foundation and published by the Scientific Scholar.