Influenza: Searching for Pandemic Origins.

IF 8.1 1区 医学 Q1 VIROLOGY
Robert G Webster
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引用次数: 0

Abstract

From a farming family of 13 children in New Zealand, I graduated with a Master of Science degree in microbiology from the University of Otago (Dunedin, Otago, New Zealand). I established the first veterinary virology laboratory at Wallaceville Animal Research Station. I subsequently completed my PhD degree at Australian National University (Canberra, Australia) and a postdoctoral fellowship at the University of Michigan (Ann Arbor, Michigan). While in New South Wales, Australia, a walk on a beach littered with dead mutton birds (shearwaters) with Dr. Graeme Laver led to the surveillance of influenza in seabirds on the Great Barrier Reef Islands and my lifelong search for the origin of pandemic influenza viruses. Subsequent studies established that (a) aquatic birds are a natural reservoir of influenza A viruses, (b) these viruses replicate primarily in cells lining the intestinal tract, (c) reassortment in nature can lead to novel pandemic influenza viruses, and (d) live bird markets are one place where transmission of influenza virus from animals to humans occurs.

流感:寻找流行病的起源。
我来自新西兰一个有13个孩子的农业家庭,毕业于奥塔哥大学(新西兰奥塔哥达尼丁),获得微生物学理学硕士学位。我在Wallaceville动物研究站建立了第一个兽医病毒学实验室。随后,我在澳大利亚国立大学(澳大利亚堪培拉)完成了博士学位,并在密歇根大学(密歇根州安娜堡)完成了博士后研究。在澳大利亚新南威尔士州期间,与Graeme Laver博士一起在海滩上散步,海滩上到处都是死去的肉禽(剪羊毛),这让我对大堡礁群岛海鸟的流感进行了监测,并让我终生寻找大流行性流感病毒的起源。随后的研究证实,(a)水生鸟类是甲型流感病毒的天然宿主,(b)这些病毒主要在肠道细胞中复制,(c)自然界中的重组可能导致新的大流行性流感病毒,(d)活禽市场是流感病毒从动物传播给人类的地方之一。
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来源期刊
CiteScore
19.40
自引率
0.90%
发文量
28
期刊介绍: The Annual Review of Virology serves as a conduit for disseminating thrilling advancements in our comprehension of viruses spanning animals, plants, bacteria, archaea, fungi, and protozoa. Its reviews illuminate novel concepts and trajectories in basic virology, elucidating viral disease mechanisms, exploring virus-host interactions, and scrutinizing cellular and immune responses to virus infection. These reviews underscore the exceptional capacity of viruses as potent probes for investigating cellular function.
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