Correcting Posterior Paraspinal Muscle Computed Tomography Density for Intravenous Contrast Material Independent of Sex and Vascular Phase.

IF 2 4区 医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Jevin Lortie, Benjamin Rush, Grace Gage, Ravi Dhingra, Scott Hetzel, Perry J Pickhardt, Timothy P Szczykutowicz, Adam J Kuchnia
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Abstract

Purpose: Intravenous contrast poses challenges to computed tomography (CT) muscle density analysis. We developed and tested corrections for contrast-enhanced CT muscle density to improve muscle analysis and the utility of CT scans for the assessment of myosteatosis.

Materials and methods: Using retrospective images from 240 adults who received routine abdominal CT imaging from March to November 2020 with weight-based iodine contrast, we obtained paraspinal muscle density measurements from noncontrast (NC), arterial, and venous-phase images. We used a calibration sample to develop 9 different mean and regression-based corrections for the effect of contrast. We applied the corrections in a validation sample and conducted equivalence testing.

Results: We evaluated 140 patients (mean age 52.0 y [SD: 18.3]; 60% female) in the calibration sample and 100 patients (mean age 54.8 y [SD: 18.9]; 60% female) in the validation sample. Contrast-enhanced muscle density was higher than NC by 8.6 HU (SD: 6.2) for the arterial phase (female, 10.4 HU [SD: 5.7]; male, 6.0 HU [SD:6.0]) and by 6.4 HU [SD:8.1] for the venous phase (female, 8.0 HU [SD: 8.6]; male, 4.0 HU [SD: 6.6]). Corrected contrast-enhanced and NC muscle density was equivalent within 3 HU for all correctionns. The -7.5 HU correction, independent of sex and phase, performed well for arterial (95% CI: -0.18, 1.80 HU) and venous-phase data (95% CI: -0.88, 1.41 HU).

Conclusions: Our validated correction factor of -7.5 HU renders contrast-enhanced muscle density statistically similar to NC density and is a feasible rule-of-thumb for clinicians to implement.

校正与性别和血管期无关的静脉造影剂的椎管后肌计算机断层扫描密度。
目的:静脉造影对计算机断层扫描(CT)肌肉密度分析提出了挑战。我们开发并测试了对比增强CT肌肉密度的校正,以改进肌肉分析和CT扫描在评估肌肉脂肪变性中的实用性。材料和方法:使用240名成年人的回顾性图像,这些成年人在2020年3月至11月接受了常规腹部CT成像,并进行了基于重量的碘造影,我们从非光栅(NC)、动脉和静脉期图像中获得了棘旁肌密度测量值。我们使用校准样本对对比度的影响进行了9种不同的平均值和基于回归的校正。我们在验证样本中应用了校正,并进行了等效性测试。结果:我们评估了校准样本中的140名患者(平均年龄52.0岁[SD:18.3];60%为女性)和验证样本中的100名患者(均值54.8岁[SD:18.9];60%女性)。动脉期(女性,10.4 HU[SD:5.7];男性,6.0 HU[SD:6.0])对比增强肌肉密度比NC高8.6 HU(SD:6.2),静脉期(女性8.0 HU[SB:8.6];男性4.0 HU[SD=6.6])对比加强肌肉密度比正常对照高6.4 HU[SID:8.1]。所有校正的对比增强和NC肌肉密度在3 HU内相等。-7.5 HU校正,与性别和分期无关,在动脉期(95%CI:-0.18,1.80 HU)和静脉期数据(95%CI:-0.88,1.41 HU)中表现良好。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Thoracic Imaging
Journal of Thoracic Imaging 医学-核医学
CiteScore
7.10
自引率
9.10%
发文量
87
审稿时长
6-12 weeks
期刊介绍: Journal of Thoracic Imaging (JTI) provides authoritative information on all aspects of the use of imaging techniques in the diagnosis of cardiac and pulmonary diseases. Original articles and analytical reviews published in this timely journal provide the very latest thinking of leading experts concerning the use of chest radiography, computed tomography, magnetic resonance imaging, positron emission tomography, ultrasound, and all other promising imaging techniques in cardiopulmonary radiology. Official Journal of the Society of Thoracic Radiology: Japanese Society of Thoracic Radiology Korean Society of Thoracic Radiology European Society of Thoracic Imaging.
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