Immune evasion on the nanoscale: Small extracellular vesicles in pancreatic ductal adenocarcinoma immunity

IF 12.1 1区医学 Q1 ONCOLOGY

Seminars in cancer biology Pub Date : 2023-09-23 DOI:10.1016/j.semcancer.2023.09.004

Jordan Fyfe , Danielle Dye , Norbaini Binti Abdol Razak , Pat Metharom , Marco Falasca

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引用次数: 0

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is a type of cancer alarmingly expanding in our modern societies that is still proving to be very challenging to counteract. This disease constitutes a quintessential example of the multiple interactions existing between the tumour and its surrounding microenvironment. In particular, PDAC is characterized by a very immunosuppressive environment that favours cancer growth and makes this cancer type very resistant to immunotherapy. The primary tumour releases many factors that influence both the microenvironment and the immune landscape. Extracellular vesicles (EVs), recently identified as indispensable entities ensuring cell-to-cell communication in both physiological and pathological processes, seem to play a pivotal function in ensuring the delivery of these factors to the tumour-surrounding tissues. In this review, we summarize the present understanding on the crosstalk among tumour cells and the cellular immune microenvironment emphasizing the pro-malignant role played by extracellular vesicles. We also discuss how a greater knowledge of the roles of EVs in tumour immune escape could be translated into clinical applications.

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纳米级免疫逃避：胰腺导管腺癌免疫中的细胞外小泡。

胰腺导管腺癌（PDAC）是一种癌症，在我们的现代社会中正在惊人地扩展，这仍然被证明是非常具有挑战性的。这种疾病是肿瘤及其周围微环境之间存在多种相互作用的典型例子。特别是，PDAC的特点是免疫抑制环境非常好，有利于癌症的生长，并使这种癌症类型对免疫疗法非常具有抵抗力。原发性肿瘤释放出许多影响微环境和免疫景观的因素。细胞外小泡（EVs）最近被确定为在生理和病理过程中确保细胞间通信的不可或缺的实体，似乎在确保这些因子传递到肿瘤周围组织方面发挥着关键作用。在这篇综述中，我们总结了目前对肿瘤细胞和细胞免疫微环境之间串扰的理解，强调了细胞外小泡所起的促恶性作用。我们还讨论了如何将对EVs在肿瘤免疫逃逸中的作用的更多了解转化为临床应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Seminars in cancer biology 医学-肿瘤学

CiteScore

26.80

自引率

4.10%

发文量

347

审稿时长

15.1 weeks

期刊介绍： Seminars in Cancer Biology (YSCBI) is a specialized review journal that focuses on the field of molecular oncology. Its primary objective is to keep scientists up-to-date with the latest developments in this field. The journal adopts a thematic approach, dedicating each issue to an important topic of interest to cancer biologists. These topics cover a range of research areas, including the underlying genetic and molecular causes of cellular transformation and cancer, as well as the molecular basis of potential therapies. To ensure the highest quality and expertise, every issue is supervised by a guest editor or editors who are internationally recognized experts in the respective field. Each issue features approximately eight to twelve authoritative invited reviews that cover various aspects of the chosen subject area. The ultimate goal of each issue of YSCBI is to offer a cohesive, easily comprehensible, and engaging overview of the selected topic. The journal strives to provide scientists with a coordinated and lively examination of the latest developments in the field of molecular oncology.