A Distinctive Pattern of Diversity for the TAS2R38 Gene in North Africa.

4区生物学 Q2 Medicine

Human Biology Pub Date : 2021-01-01 DOI:10.1353/hub.2021.0009

Soufia Mourali-Chebil, Sarra Elkamel, Sami Boussetta, Andrew J Pakstis, Kenneth K Kidd, Amel Benammar-Elgaaied, Lotfi Cherni

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引用次数: 0

Abstract

The TAS2R38 gene is involved in bitter taste perception. This study documents the distinctive diversity patterns in northern Africa of functional single-nucleotide polymorphisms (SNPs) rs713598 and rs1726866 at the TAS2R38 locus and places those patterns in the context of global TAS2R38 diversity. Data previously genotyped with TaqMan assay were analyzed for rs713598 and rs1726866 for 375 unrelated subjects (305 Tunisians from seven locations: Mahdia, Sousse, Kesra, Nebeur, Kairouan, Smar, and Kerkennah; plus 70 Libyans). Data were analyzed to present haplotypes and genotypes before comparison with data from worldwide populations. This study provides information about TAS2R38 diversity in a part of the world that is relatively understudied. Considering the two SNPs rs713598 and rs1726866, the CA nucleotide haplotype leading to the PV amino acid haplotype is extremely rare almost everywhere, but it is relatively frequent (between 6% and 15%) in northern Africa, where it coexists with the globally common amino acid haplotypes PA, AA, and AV. Given its higher frequency in North Africa, the authors propose the CA nucleotide haplotype as a biogeographic marker for forensic purposes.

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北非TAS2R38基因的一种独特多样性模式。

TAS2R38基因参与苦味感知。本研究记录了非洲北部TAS2R38基因座功能性单核苷酸多态性（SNPs）rs713598和rs1726866的独特多样性模式，并将这些模式置于全球TAS2R33多样性的背景下。对375名无关受试者（来自七个地区的305名突尼斯人：Mahdia、Sousse、Kesra、Nebeur、Kairouan、Smar和Kerkennah；加上70名利比亚人）的rs713598和rs1726866基因型数据进行了分析。在与世界各地人群的数据进行比较之前，对数据进行了分析，以呈现单倍型和基因型。这项研究提供了关于TAS2R38在世界上研究相对不足的地区的多样性的信息。考虑到两个SNPs rs713598和rs1726866，导致PV氨基酸单倍型的CA核苷酸单倍型几乎在任何地方都极为罕见，但在北非相对频繁（6%至15%），在那里它与全球常见的氨基酸单倍型PA、AA和AV共存。鉴于其在北非的频率较高，作者提出将CA核苷酸单倍型作为生物地理标记用于法医学目的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Human Biology 生物-生物学

CiteScore

1.90

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Human Biology publishes original scientific articles, brief communications, letters to the editor, and review articles on the general topic of biological anthropology. Our main focus is understanding human biological variation and human evolution through a broad range of approaches. We encourage investigators to submit any study on human biological diversity presented from an evolutionary or adaptive perspective. Priority will be given to interdisciplinary studies that seek to better explain the interaction between cultural processes and biological processes in our evolution. Methodological papers are also encouraged. Any computational approach intended to summarize cultural variation is encouraged. Studies that are essentially descriptive or concern only a limited geographic area are acceptable only when they have a wider relevance to understanding human biological variation. Manuscripts may cover any of the following disciplines, once the anthropological focus is apparent: human population genetics, evolutionary and genetic demography, quantitative genetics, evolutionary biology, ancient DNA studies, biological diversity interpreted in terms of adaptation (biometry, physical anthropology), and interdisciplinary research linking biological and cultural diversity (inferred from linguistic variability, ethnological diversity, archaeological evidence, etc.).