Circulating Concentrations of advanced Glycation end Products, Carboxymethyl Lysine and Methylglyoxal are Associated With Renal Function in Individuals With Diabetes

IF 3.4 3区医学 Q2 NUTRITION & DIETETICS

Journal of Renal Nutrition Pub Date : 2024-03-01 DOI:10.1053/j.jrn.2023.09.005

Lina Ding MD , Yanli Hou MD , Junjun Liu PhD , Xiaolei Wang PhD , Zhibin Wang MD , Wenyu Ding MD , Ke Zhao MD

{"title":"Circulating Concentrations of advanced Glycation end Products, Carboxymethyl Lysine and Methylglyoxal are Associated With Renal Function in Individuals With Diabetes","authors":"Lina Ding MD , Yanli Hou MD , Junjun Liu PhD , Xiaolei Wang PhD , Zhibin Wang MD , Wenyu Ding MD , Ke Zhao MD","doi":"10.1053/j.jrn.2023.09.005","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><p>Diabetic kidney disease<span><span> (DKD) is one of the most severe chronic complications of diabetes and is associated with higher level of </span>advanced glycation end products (AGEs). The aim of this study was to investigate the diagnostic potential of combined detection of multiple serum AGEs in diagnosing DKD.</span></p></div><div><h3>Methods</h3><p>Serum AGEs, N<sup>ε</sup>-(carboxymethyl) lysine (CML), N<sup>ε</sup><span><span>-(carboxyethyl) lysine, and methylglyoxal<span> (MGO) levels were measured by enzyme-linked immunosorbent assay in 176 individuals with type 2 diabetes. Participants were classified into normoalbuminuria, microalbuminuria, and </span></span>macroalbuminuria<span> group according to their urinary albumin to creatinine ratio (UACR).</span></span></p></div><div><h3>Results</h3><p><span><span>Higher serum AGEs levels were found to be positively correlated with U-Alb, UACR, and blood urea nitrogen in the study of 176 individuals with type 2 diabetes. CML and MGO levels were positively correlated with U-Alb, UACR, blood urea nitrogen, Scr, and </span>uric acid<span>, and negatively correlated with estimated glomerular filtration rate (</span></span><em>P</em><span> < .05). Multivariate logistic regression analysis showed that elevated levels of AGEs, CML, and MGO were independent risk factors for the progression of DKD (odds ratio = 1.861, 1.016, 7.607, </span><em>P</em> < .01). The sensitivity, specificity, and area under receiver operating characteristic curve of combined detection of AGEs, MGO, and CML were higher than those of three individual detections (area under the curve = 0.952, 0.772, 0.868, 0905, respectively, <em>P</em> < .05).</p></div><div><h3>Conclusion</h3><p>The combined detection of AGEs, CML, and MGO may improve the reliability of early diagnosis of DKD.</p></div>","PeriodicalId":50066,"journal":{"name":"Journal of Renal Nutrition","volume":null,"pages":null},"PeriodicalIF":3.4000,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Renal Nutrition","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1051227623001553","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"NUTRITION & DIETETICS","Score":null,"Total":0}

引用次数: 0

Abstract

Objective

Diabetic kidney disease (DKD) is one of the most severe chronic complications of diabetes and is associated with higher level of advanced glycation end products (AGEs). The aim of this study was to investigate the diagnostic potential of combined detection of multiple serum AGEs in diagnosing DKD.

Methods

Serum AGEs, N^ε-(carboxymethyl) lysine (CML), N^ε-(carboxyethyl) lysine, and methylglyoxal (MGO) levels were measured by enzyme-linked immunosorbent assay in 176 individuals with type 2 diabetes. Participants were classified into normoalbuminuria, microalbuminuria, and macroalbuminuria group according to their urinary albumin to creatinine ratio (UACR).

Results

Higher serum AGEs levels were found to be positively correlated with U-Alb, UACR, and blood urea nitrogen in the study of 176 individuals with type 2 diabetes. CML and MGO levels were positively correlated with U-Alb, UACR, blood urea nitrogen, Scr, and uric acid, and negatively correlated with estimated glomerular filtration rate (P < .05). Multivariate logistic regression analysis showed that elevated levels of AGEs, CML, and MGO were independent risk factors for the progression of DKD (odds ratio = 1.861, 1.016, 7.607, P < .01). The sensitivity, specificity, and area under receiver operating characteristic curve of combined detection of AGEs, MGO, and CML were higher than those of three individual detections (area under the curve = 0.952, 0.772, 0.868, 0905, respectively, P < .05).

Conclusion

The combined detection of AGEs, CML, and MGO may improve the reliability of early diagnosis of DKD.

查看原文本刊更多论文

循环中晚期糖基化终产物、羧甲基赖氨酸和甲基乙二醛的浓度与糖尿病患者的肾功能有关。

目的：糖尿病肾病（DKD）是糖尿病最严重的慢性并发症之一，与晚期糖基化终产物（AGEs）水平较高有关。本研究的目的是探讨多种血清AGEs联合检测在诊断DKD中的诊断潜力。方法：采用ELISA法测定176例2型糖尿病（T2D）患者血清AGEs、Nε-。参与者根据其尿白蛋白与肌酐比值（UACR）分为正常组（NAU组）、微量组（MAU组）和大量白蛋白尿组（MAAU组）。结果：血清AGEs水平升高与U-Alb、UACR、BUN呈正相关；CML和MGO水平与U-Alb、UACR、BUN、Scr和UA呈正相关，与eGFR呈负相关（P结论：AGEs、CML和MGO联合检测可提高DKD早期诊断的可靠性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of Renal Nutrition 医学-泌尿学与肾脏学

CiteScore

5.70

自引率

12.50%

发文量

146

审稿时长

6.7 weeks

期刊介绍： The Journal of Renal Nutrition is devoted exclusively to renal nutrition science and renal dietetics. Its content is appropriate for nutritionists, physicians and researchers working in nephrology. Each issue contains a state-of-the-art review, original research, articles on the clinical management and education of patients, a current literature review, and nutritional analysis of food products that have clinical relevance.