Association between triglyceride glucose index and severity of diabetic foot ulcers in type 2 diabetes mellitus.

IF 2.5 3区医学 Q1 ORTHOPEDICS

Journal of Foot and Ankle Research Pub Date : 2023-10-05 DOI:10.1186/s13047-023-00663-7

Weihao Chen, Xuedong Wang, Qilin Jiang, Jiyan Wu, Wanyan Shi, Xiaoxiao Wang, Yihu Yin, Jiayin Zheng, Xiang Hu, Cai Lin, Xingxing Zhang

{"title":"Association between triglyceride glucose index and severity of diabetic foot ulcers in type 2 diabetes mellitus.","authors":"Weihao Chen, Xuedong Wang, Qilin Jiang, Jiyan Wu, Wanyan Shi, Xiaoxiao Wang, Yihu Yin, Jiayin Zheng, Xiang Hu, Cai Lin, Xingxing Zhang","doi":"10.1186/s13047-023-00663-7","DOIUrl":null,"url":null,"abstract":"Background: Triglyceride glucose (TyG) index is a good surrogate biomarker to evaluate insulin resistance (IR). The study aimed to investigate whether the TyG index is related to the severity of diabetic foot ulcers (DFUs) in patients with type 2 diabetes mellitus (T2DM).Methods: A total of 1059 T2DM patients were enrolled in this observational, retrospective, single-center study. TyG index was calculated as ln[fasting triglycerides (mg/dl) × fasting glucose (mg/ dl)/2]. The severity of DFUs was classified into mild-to-moderate DFUs (Wagner grade score < 3) and severe DFUs (Wagner grade score ≥ 3) based on Wagner classification. Patients were stratified according to the tertiles of TyG index. Logistic regression models were implemented to explore the association between TyG index and the severity of DFUs. Subgroup analyses were used to verify the reliability of results.Results: Compared with the reference lowest TyG tertile (T1), the highest tertile (T3) was associated with 0.377-fold increased risk of prevalence of severe DFUs (odds ratio [OR] 1.377, 95% confidence interval [CI] 1.017-1.865) (P = 0.039). After adjusting for potential confounders, the multivariable-adjusted OR and 95% CI were 1.506 (1.079-2.103) (P = 0.016) in patients with highest tertile. Moreover, subgroup analyses indicated that the association was stronger among men, patients with age ≥ 65 years, duration of diabetes more than 10 years, or without PAD.Conclusions: Elevated TyG index is independently associated with severity of DFUs even after adjusting conventional confounders.","PeriodicalId":49164,"journal":{"name":"Journal of Foot and Ankle Research","volume":"16 1","pages":"68"},"PeriodicalIF":2.5000,"publicationDate":"2023-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10552301/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Foot and Ankle Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s13047-023-00663-7","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ORTHOPEDICS","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Triglyceride glucose (TyG) index is a good surrogate biomarker to evaluate insulin resistance (IR). The study aimed to investigate whether the TyG index is related to the severity of diabetic foot ulcers (DFUs) in patients with type 2 diabetes mellitus (T2DM).

Methods: A total of 1059 T2DM patients were enrolled in this observational, retrospective, single-center study. TyG index was calculated as ln[fasting triglycerides (mg/dl) × fasting glucose (mg/ dl)/2]. The severity of DFUs was classified into mild-to-moderate DFUs (Wagner grade score < 3) and severe DFUs (Wagner grade score ≥ 3) based on Wagner classification. Patients were stratified according to the tertiles of TyG index. Logistic regression models were implemented to explore the association between TyG index and the severity of DFUs. Subgroup analyses were used to verify the reliability of results.

Results: Compared with the reference lowest TyG tertile (T1), the highest tertile (T3) was associated with 0.377-fold increased risk of prevalence of severe DFUs (odds ratio [OR] 1.377, 95% confidence interval [CI] 1.017-1.865) (P = 0.039). After adjusting for potential confounders, the multivariable-adjusted OR and 95% CI were 1.506 (1.079-2.103) (P = 0.016) in patients with highest tertile. Moreover, subgroup analyses indicated that the association was stronger among men, patients with age ≥ 65 years, duration of diabetes more than 10 years, or without PAD.

Conclusions: Elevated TyG index is independently associated with severity of DFUs even after adjusting conventional confounders.

Abstract Image

查看原文本刊更多论文

甘油三酯-葡萄糖指数与2型糖尿病足溃疡严重程度的关系。

背景：甘油三酯-葡萄糖（TyG）指数是评价胰岛素抵抗（IR）的良好替代生物标志物。本研究旨在探讨TyG指数是否与2型糖尿病（T2DM）患者糖尿病足溃疡（DFU）的严重程度有关。方法：共有1059名T2DM患者参加了这项观察性、回顾性、单中心研究。TyG指数计算为ln[空腹甘油三酯（mg/dl） × 空腹血糖（mg/dl）/2]。DFU的严重程度分为轻度至中度DFU（Wagner评分结果：与参考的最低TyG三分位（T1）相比，最高三分位数（T3）与严重DFU患病风险增加0.377倍有关（比值比[OR]1.377，95%置信区间[CI]1.017-1.865）（P = 校正潜在混杂因素后，多变量校正OR和95%CI分别为1.506（1.079-2.103）（P = 0.016）。此外，亚组分析表明，男性患者与年龄的相关性更强 ≥ 65岁，糖尿病持续时间超过10年，或无PAD。结论：即使在调整了常规混杂因素后，TyG指数升高也与DFU的严重程度独立相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of Foot and Ankle Research ORTHOPEDICS-

CiteScore

4.50

自引率

10.30%

发文量

审稿时长

>12 weeks

期刊介绍： Journal of Foot and Ankle Research, the official journal of the Australian Podiatry Association and The College of Podiatry (UK), is an open access journal that encompasses all aspects of policy, organisation, delivery and clinical practice related to the assessment, diagnosis, prevention and management of foot and ankle disorders. Journal of Foot and Ankle Research covers a wide range of clinical subject areas, including diabetology, paediatrics, sports medicine, gerontology and geriatrics, foot surgery, physical therapy, dermatology, wound management, radiology, biomechanics and bioengineering, orthotics and prosthetics, as well the broad areas of epidemiology, policy, organisation and delivery of services related to foot and ankle care. The journal encourages submissions from all health professionals who manage lower limb conditions, including podiatrists, nurses, physical therapists and physiotherapists, orthopaedists, manual therapists, medical specialists and general medical practitioners, as well as health service researchers concerned with foot and ankle care. The Australian Podiatry Association and the College of Podiatry (UK) have reserve funds to cover the article-processing charge for manuscripts submitted by its members. Society members can email the appropriate contact at Australian Podiatry Association or The College of Podiatry to obtain the corresponding code to enter on submission.