Sex Hormone-Binding Globulin and Risk of Incident Dementia in Middle-Aged to Older Women: Results from the UK Biobank Cohort Study.

IF 3.2 2区医学 Q2 ENDOCRINOLOGY & METABOLISM

Neuroendocrinology Pub Date : 2024-01-01 Epub Date: 2023-09-19 DOI:10.1159/000533929

Junlin Huang, Bingyan Xu, Xiaomin Chen, Linjie Yang, Deying Liu, Jiayang Lin, Yating Liu, Xuzhen Lei, Chensihan Huang, Weijuan Dou, Dan Guo, Xueyun Wei, Peizhen Zhang, Yan Huang, Xuejiang Gu, Huijie Zhang

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引用次数: 0

Abstract

Introduction: The association of serum sex hormone-binding globulin (SHBG) concentrations with dementia risk remains uncertain in middle-aged to older women. We examined associations of serum SHBG levels with incidence of all-cause dementia and its subtypes in middle-aged to older women from the large population-based UK Biobank cohort study.

Methods: Serum total SHBG levels were measured by immunoassay. The incidence of all-cause dementia and its subtypes was recorded. Cox proportional hazards models were used to calculate hazard ratios (HR) for main outcomes.

Results: Among 171,482 community-dwelling women (mean [SD] age was 59.9 [5.4] years, median follow-up of 11.8 years), 2,368 developed dementia, including 1,088 from Alzheimer's disease (AD), 451 from vascular dementia (VAD), and 1,609 from other dementia. After multivariable adjustments, higher serum SHBG levels were significantly associated with higher risks of all-cause dementia, AD, and other dementia (all p < 0.05). Compared to those in the lowest quartile of SHBG levels, participants in the highest quartile of SHBG levels had a higher risk of all-cause dementia (HR: 1.34; 95% confidence interval [CI]: 1.16-1.53), AD (HR: 1.32; 95% CI: 1.07-1.62), and other dementia (HR: 1.44; 95% CI: 1.21-1.70). However, this relationship was not significant for VAD (HR: 1.16; 95% CI: 0.86-1.56).

Conclusion: These findings indicated that higher serum SHBG concentrations were independently associated with higher risks of incident all-cause dementia, as well as AD and other dementia among middle-aged to older women. No association was found for VAD.

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性激素结合球蛋白与中老年女性发生痴呆的风险：英国生物库队列研究结果。

引言：血清性激素结合球蛋白（SHBG）浓度与中老年女性痴呆风险的关系尚不确定。我们在英国生物银行的大型人群队列研究中检测了血清SHBG水平与中老年女性全因痴呆及其亚型发病率的关系。方法：采用免疫分析法测定血清总SHBG水平。记录全因性痴呆的发生率及其亚型。Cox比例风险模型用于计算主要结果的风险比（HR）。结果：在171482名社区女性中（平均（SD）年龄为59.9（5.4）岁，中位随访11.8年），2368人患上痴呆症，其中1088人患有阿尔茨海默病，451人患有血管性痴呆，1609人患有其他痴呆。多变量调整后，较高的血清SHBG水平与较高的全因痴呆风险显著相关，AD和其他痴呆症（所有结论：这些发现表明，在中老年女性中，较高的血清SHBG浓度与发生全因痴呆症以及AD和其他失智症的风险较高独立相关。未发现与VAD相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuroendocrinology 医学-内分泌学与代谢

CiteScore

8.30

自引率

2.40%

发文量

审稿时长

6-12 weeks

期刊介绍： ''Neuroendocrinology'' publishes papers reporting original research in basic and clinical neuroendocrinology. The journal explores the complex interactions between neuronal networks and endocrine glands (in some instances also immunecells) in both central and peripheral nervous systems. Original contributions cover all aspects of the field, from molecular and cellular neuroendocrinology, physiology, pharmacology, and the neuroanatomy of neuroendocrine systems to neuroendocrine correlates of behaviour, clinical neuroendocrinology and neuroendocrine cancers. Readers also benefit from reviews by noted experts, which highlight especially active areas of current research, and special focus editions of topical interest.