Association between Helicobacter pylori Infection and Eosinophilic Esophagitis.

The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi Pub Date : 2023-09-25 DOI:10.4166/kjg.2023.037

Young Hoon Chang, Cheol Min Shin, Dong Ho Lee, Hyuk Yoon, Young Soo Park, Nayoung Kim

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Abstract

Background/aims: This study examined the association between eosinophilic esophagitis (EoE) and Helicobacter pylori (H. pylori) infection.

Methods: A single tertiary referral center case-control study was performed. EoE patients diagnosed at Seoul National University Bundang Hospital from July 2003 to March 2022 were reviewed retrospectively. Forty-five EoE patients were included in the analysis. For each EoE patient, two age and sex-matched normal controls were selected randomly from an outpatient population who received upper gastrointestinal endoscopy.

Results: Although 17 out of 90 (18.9%) controls had a H. pylori infection, only two out of 45 (4.4%) EoE patients showed evidence of a H. pylori infection. EoE was inversely associated with a H. pylori infection (odds ratio 0.20, 95% confidence interval 0.04-0.91, p=0.044).

Conclusions: An inverse association was observed between H. pylori infection and EoE. Further prospective studies will be needed to validate the protective effects of H. pylori infection for EoE.

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幽门螺杆菌感染与嗜酸性食管炎的关系。

背景/目的：本研究探讨了嗜酸性食管炎（EoE）与幽门螺杆菌（H.pylori）感染之间的关系。方法：采用单一三级转诊中心病例对照研究。对2003年7月至2022年3月在首尔国立大学Bundang医院诊断的EoE患者进行回顾性分析。45名EoE患者被纳入分析。对于每个EoE患者，从接受上消化道内窥镜检查的门诊人群中随机选择两名年龄和性别匹配的正常对照。结果：尽管90名对照中有17人（18.9%）感染了幽门螺杆菌，但45名EoE患者中只有2人（4.4%）显示出幽门螺杆菌感染的证据。EoE与幽门螺杆菌感染呈负相关（比值比0.20，95%置信区间0.04-0.91，p=0.044）。需要进一步的前瞻性研究来验证幽门螺杆菌感染对EoE的保护作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi

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