The Results of the URRAH (Uric Acid Right for Heart Health) Project: A Focus on Hyperuricemia in Relation to Cardiovascular and Kidney Disease and its Role in Metabolic Dysregulation.

IF 3.1 Q2 PERIPHERAL VASCULAR DISEASE
Alessandro Maloberti, Alessandro Mengozzi, Elisa Russo, Arrigo Francesco Giuseppe Cicero, Fabio Angeli, Enrico Agabiti Rosei, Carlo Maria Barbagallo, Bruno Bernardino, Michele Bombelli, Federica Cappelli, Edoardo Casiglia, Rosario Cianci, Michele Ciccarelli, Massimo Cirillo, Pietro Cirillo, Giovambattista Desideri, Lanfranco D'Elia, Raffaella Dell'Oro, Rita Facchetti, Claudio Ferri, Ferruccio Galletti, Cristina Giannattasio, Loreto Gesualdo, Guido Iaccarino, Luciano Lippa, Francesca Mallamaci, Stefano Masi, Maria Masulli, Alberto Mazza, Maria Lorenza Muiesan, Pietro Nazzaro, Gianfranco Parati, Paolo Palatini, Paolo Pauletto, Roberto Pontremoli, Nicola Riccardo Pugliese, Fosca Quarti-Trevano, Marcello Rattazzi, Gianpaolo Reboldi, Giulia Rivasi, Massimo Salvetti, Valerie Tikhonoff, Giuliano Tocci, Andrea Ungar, Paolo Verdecchia, Francesca Viazzi, Massimo Volpe, Agostino Virdis, Guido Grassi, Claudio Borghi
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引用次数: 3

Abstract

The relationship between Serum Uric Acid (UA) and Cardiovascular (CV) diseases has already been extensively evaluated, and it was found to be an independent predictor of all-cause and cardiovascular mortality but also acute coronary syndrome, stroke and heart failure. Similarly, also many papers have been published on the association between UA and kidney function, while less is known on the role of UA in metabolic derangement and, particularly, in metabolic syndrome. Despite the substantial number of publications on the topic, there are still some elements of doubt: (1) the better cut-off to be used to refine CV risk (also called CV cut-off); (2) the needing for a correction of UA values for kidney function; and (3) the better definition of its role in metabolic syndrome: is UA simply a marker, a bystander or a key pathological element of metabolic dysregulation?. The Uric acid Right for heArt Health (URRAH) project was designed by the Working Group on uric acid and CV risk of the Italian Society of Hypertension to answer the first question. After the first papers that individuates specific cut-off for different CV disease, subsequent articles have been published responding to the other relevant questions. This review will summarise most of the results obtained so far from the URRAH research project.

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URRAH(尿酸对心脏健康的权利)项目的结果:关注与心血管和肾脏疾病相关的高尿酸血症及其在代谢失调中的作用。
血清尿酸(UA)与心血管疾病(CV)之间的关系已经得到了广泛的评估,它被发现是全因和心血管死亡率的独立预测因子,也是急性冠状动脉综合征、中风和心力衰竭的独立预测因素。同样,也发表了许多关于UA与肾功能之间关系的论文,而对UA在代谢紊乱,特别是代谢综合征中的作用知之甚少。尽管有大量关于该主题的出版物,但仍存在一些疑问:(1)用于细化CV风险的更好的截止值(也称为CV截止值);(2) 需要校正肾功能的UA值;以及(3)更好地定义其在代谢综合征中的作用:UA只是代谢失调的标志物、旁观者还是关键病理因素?。尿酸健康权(URRAH)项目是由意大利高血压学会尿酸和心血管风险工作组设计的,旨在回答第一个问题。在第一篇论文对不同心血管疾病的具体界限进行了个性化研究之后,随后的文章也发表了,对其他相关问题做出了回应。本综述将总结URRAH研究项目迄今为止获得的大部分结果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
5.70
自引率
3.30%
发文量
57
期刊介绍: High Blood Pressure & Cardiovascular Prevention promotes knowledge, update and discussion in the field of hypertension and cardiovascular disease prevention, by providing a regular programme of independent review articles covering key aspects of the management of hypertension and cardiovascular diseases. The journal includes:   Invited ''State of the Art'' reviews.  Expert commentaries on guidelines, major trials, technical advances.Presentation of new intervention trials design.''Pros and Cons'' or round tables on controversial issues.Statements on guidelines from hypertension and cardiovascular scientific societies.Socio-economic issues.Cost/benefit in prevention of cardiovascular diseases.Monitoring of healthcare systems.News and views from the Italian Society of Hypertension (including abstracts).All manuscripts are subject to peer review by international experts. Letters to the editor are welcomed and will be considered for publication.
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