Increased theta-low gamma phase-amplitude coupling in resting electroencephalography after intermittent theta burst stimulation

IF 2.7 4区医学 Q2 CLINICAL NEUROLOGY

Neurophysiologie Clinique/Clinical Neurophysiology Pub Date : 2023-10-01 DOI:10.1016/j.neucli.2023.102899

Jie Zhang , Chunwei Ying , Zhenying Qian , Xiong Jiao , Xiaochen Tang , Gai Kong , Junfeng Sun , Jijun Wang , Yingying Tang

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引用次数: 0

Abstract

Objective

Intermittent theta burst stimulation (iTBS) is based on the phase-amplitude coupling (PAC) pattern. We aimed to investigate the effect of iTBS on PAC in resting electroencephalography (EEG), which may provide insight into the underlying mechanism.

Methods

Twenty-one healthy volunteers were recruited and received both active and sham neuroimaging-guided iTBS on two separate days, which was precisely delivered to the right superior temporal gyrus. On each experimental day, resting EEG was recorded before and after stimulation for each participant. PACs across electrodes and frequency bands were calculated and compared to investigate the effect of iTBS.

Results

Theta (4–6 Hz) -low gamma (45–55 Hz) PAC over the stimulation site had a significant interaction effect, which increased after the active iTBS but did not differ after the sham iTBS. No significant interaction effect occurred in other cross-frequency couplings such as delta-low gamma, alpha-low gamma, delta-high gamma, theta-high gamma, or alpha-high gamma PAC in the region of interest.

Conclusion

iTBS selectively modulated theta-low gamma PAC at the stimulation area, which exhibited both region- and frequency- specificity. This suggests that PAC may be a bridge connecting external neuromodulation to internal neuroplasticity.

查看原文本刊更多论文

间歇θ突发刺激后静息脑电图中θ低γ相位振幅耦合增加。

目的：间歇性θ突发刺激（iTBS）是基于相位-振幅耦合（PAC）模式的。我们旨在研究静息脑电图（EEG）中iTBS对PAC的影响，这可能为深入了解其潜在机制提供依据。方法：招募21名健康志愿者，分别在两天内接受活动和假神经成像引导的iTBS，并将其精确递送至右颞上回。在每个实验日，记录每个参与者在刺激前后的静息脑电图。计算并比较了电极和频带上的PAC，以研究iTBS的影响。结果：刺激部位上的Theta（4-6 Hz）-低伽马（45-55 Hz）PAC具有显著的相互作用效应，在激活iTBS后增加，但在假iTBS后没有差异。在感兴趣区域中的其他交叉频率耦合（如Δ低伽马、α低伽马、Δ高伽马、θ高伽马或α高伽马PAC）中没有发生显著的相互作用效应。结论：iTBS选择性地调节刺激区的θ低γPAC，表现出区域和频率的特异性。这表明PAC可能是连接外部神经调控和内部神经可塑性的桥梁。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurophysiologie Clinique/Clinical Neurophysiology 医学-临床神经学

CiteScore

5.20

自引率

3.30%

发文量

审稿时长

60 days

期刊介绍： Neurophysiologie Clinique / Clinical Neurophysiology (NCCN) is the official organ of the French Society of Clinical Neurophysiology (SNCLF). This journal is published 6 times a year, and is aimed at an international readership, with articles written in English. These can take the form of original research papers, comprehensive review articles, viewpoints, short communications, technical notes, editorials or letters to the Editor. The theme is the neurophysiological investigation of central or peripheral nervous system or muscle in healthy humans or patients. The journal focuses on key areas of clinical neurophysiology: electro- or magneto-encephalography, evoked potentials of all modalities, electroneuromyography, sleep, pain, posture, balance, motor control, autonomic nervous system, cognition, invasive and non-invasive neuromodulation, signal processing, bio-engineering, functional imaging.