Revising a Self-Regulation Phenotype for Depression Through Individual Differences in Macroscale Brain Organization.

IF 4.4 2区 化学 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY
ACS Applied Polymer Materials Pub Date : 2023-08-01 Epub Date: 2023-04-16 DOI:10.1177/09637214221149742
Timothy J Strauman, Ahmad R Hariri
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引用次数: 0

Abstract

Self-regulation denotes the processes by which people initiate, maintain, and control their own thoughts, behaviors, or emotions to produce a desired outcome or avoid an undesired outcome. Self-regulation brings the influence of distal factors such as biology, temperament, and socialization history onto cognition, motivation, and behavior. Dysfunction in self-regulation represents a contributory causal factor for psychopathology. Accordingly, we previously proposed a risk phenotype model for depression drawing from regulatory focus theory and traditional task-based fMRI studies. In this article, we revise and expand our risk phenotype model using insights from new methodologies allowing quantification of individual differences in task-free macroscale brain organization. We offer a set of hypotheses as examples of how examination of intrinsic macroscale brain organization can extend and enrich investigations of self-regulation and depression. In doing so, we hope to promote a useful heuristic for model development and for identifying transdiagnostic risk phenotypes in psychopathology.

从宏观脑组织的个体差异看抑郁症的自我调节表型。
自我调节是指人们启动、维持和控制自己的思想、行为或情绪,以产生期望的结果或避免不期望的结果的过程。自我调节带来了生物学、气质和社会化历史等远端因素对认知、动机和行为的影响。自我调节功能障碍是精神病理学的一个促成因素。因此,我们之前根据调节焦点理论和传统的基于任务的功能磁共振成像研究提出了抑郁症的风险表型模型。在这篇文章中,我们使用新方法的见解来修改和扩展我们的风险表型模型,从而量化无任务宏观大脑组织中的个体差异。我们提供了一组假设,作为对内在宏观大脑组织的检查如何扩展和丰富自我调节和抑郁研究的例子。通过这样做,我们希望促进一种有用的启发式方法,用于模型开发和识别精神病理学中的跨诊断风险表型。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
7.20
自引率
6.00%
发文量
810
期刊介绍: ACS Applied Polymer Materials is an interdisciplinary journal publishing original research covering all aspects of engineering, chemistry, physics, and biology relevant to applications of polymers. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrates fundamental knowledge in the areas of materials, engineering, physics, bioscience, polymer science and chemistry into important polymer applications. The journal is specifically interested in work that addresses relationships among structure, processing, morphology, chemistry, properties, and function as well as work that provide insights into mechanisms critical to the performance of the polymer for applications.
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