A CASE OF EPSTEIN-BARR VIRUS-ASSOCIATED PRIMARY VITREORETINAL LYMPHOMA IN AN IMMUNOSUPPRESSED PATIENT.

Q3 Medicine

Retinal Cases and Brief Reports Pub Date : 2025-01-01 DOI:10.1097/ICB.0000000000001500

Chunxiao Sun, Yuki Muraoka, Kenji Ishihara, Satoshi Morooka, Masahiro Akada, Masayuki Hata, Akitaka Tsujikawa

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引用次数: 0

Abstract

Purpose: To describe a rare case of Epstein-Barr virus (EBV)-positive primary vitreoretinal lymphoma in an immunosuppressed patient.

Methods: Observational case report.

Results: A 64-year-old man under immunosuppressive therapy for rheumatic arthritis was referred for 2 months of blurred vision and decreased visual acuity in the right eye. Only mutton-fat keratic precipitates and mild vitreous opacity were found in the right eye without (sub)retinal or sub-retinal pigment epithelial lesions. Vitreous biopsy and systemic workup suggested the diagnosis of primary vitreoretinal lymphoma of diffuse large B-cell lymphoma subform. Neoplastic cells stained positive for EBV antigens, EBV-encoded small RNA, and Epstein-Barr nuclear antigen 2, consistent with EBV-positive diffuse large B-cell lymphoma. Intravitreal methotrexate was effective in improving ocular symptoms.

Conclusion: The case provided evidence on the association of EBV infection with primary vitreoretinal lymphoma.

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一例免疫抑制患者的EB病毒相关原发性玻璃体视网膜淋巴瘤。

目的：描述一例罕见的免疫抑制患者的EB病毒阳性原发性玻璃体视网膜淋巴瘤。方法：观察病例报告。结果：一名64岁的男性因风湿性关节炎接受免疫抑制治疗，因右眼视力模糊和下降，转诊2个月。右眼仅发现羊脂角蛋白沉淀和轻度玻璃体混浊，无（亚）视网膜或亚视网膜色素上皮病变。玻璃体活检和全身检查提示PVRL诊断为弥漫性大B细胞淋巴瘤（DLBCL）亚型。EBV抗原、EBV编码的小RNA和Epstein-Barr核抗原2染色阳性的新生细胞，与EBV阳性的DLBCL一致。玻璃体内注射甲氨蝶呤对改善眼部症状是有效的。结论：我们的病例为EBV感染与PVRL的相关性提供了证据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Retinal Cases and Brief Reports Medicine-Ophthalmology

CiteScore

2.10

自引率

0.00%

发文量

342