Mevalonate pathway and male reproductive aging

IF 2.7 3区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular Reproduction and Development Pub Date : 2023-09-21 DOI:10.1002/mrd.23705

Jia-Le Zhang, Meng Lv, Chao-Fan Yang, Ying-Xi Zhu, Chao-Jun Li

{"title":"Mevalonate pathway and male reproductive aging","authors":"Jia-Le Zhang, Meng Lv, Chao-Fan Yang, Ying-Xi Zhu, Chao-Jun Li","doi":"10.1002/mrd.23705","DOIUrl":null,"url":null,"abstract":"<p>Male fertility declines with age. The mevalonate pathway, through which cholesterol and nonsteroidal isoprenoids are synthesized, plays key role in metabolic processes and is an essential pathway for cholesterol production and protein prenylation. Male reproductive aging is accompanied by dramatic changes in the metabolic microenvironment of the testis. Since the mevalonate pathway has an important role in spermatogenesis, we attempted to explore the association between male reproductive aging and the mevalonate pathway to explain the mechanism of male reproductive aging. Alterations in the mevalonate pathway may affect male reproductive aging by decreasing cholesterol synthesis and altering testis protein prenylation. Decreased cholesterol levels affect cholesterol modification, testosterone production, and remodeling of germ cell membranes. Aging-related metabolic disorders also affect the metabolic coupling between somatic cells and spermatogenic cells, leading to male fertility decline. Therefore, we hypothesized that alterations in the mevalonate pathway represent one of the metabolic causes of reproductive aging.</p>","PeriodicalId":18856,"journal":{"name":"Molecular Reproduction and Development","volume":"90 10-11","pages":"774-781"},"PeriodicalIF":2.7000,"publicationDate":"2023-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Molecular Reproduction and Development","FirstCategoryId":"99","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/mrd.23705","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Male fertility declines with age. The mevalonate pathway, through which cholesterol and nonsteroidal isoprenoids are synthesized, plays key role in metabolic processes and is an essential pathway for cholesterol production and protein prenylation. Male reproductive aging is accompanied by dramatic changes in the metabolic microenvironment of the testis. Since the mevalonate pathway has an important role in spermatogenesis, we attempted to explore the association between male reproductive aging and the mevalonate pathway to explain the mechanism of male reproductive aging. Alterations in the mevalonate pathway may affect male reproductive aging by decreasing cholesterol synthesis and altering testis protein prenylation. Decreased cholesterol levels affect cholesterol modification, testosterone production, and remodeling of germ cell membranes. Aging-related metabolic disorders also affect the metabolic coupling between somatic cells and spermatogenic cells, leading to male fertility decline. Therefore, we hypothesized that alterations in the mevalonate pathway represent one of the metabolic causes of reproductive aging.

Abstract Image

查看原文本刊更多论文

甲羟戊酸途径与男性生殖衰老。

男性生育能力随着年龄的增长而下降。甲羟戊酸途径是合成胆固醇和非甾体类异戊二烯的途径，在代谢过程中起着关键作用，是胆固醇产生和蛋白质异戊二烯化的重要途径。男性生殖衰老伴随着睾丸代谢微环境的急剧变化。由于甲羟戊酸途径在精子发生中起着重要作用，我们试图探索男性生殖衰老与甲羟戊酸盐途径之间的联系，以解释男性生殖衰老的机制。甲羟戊酸途径的改变可能通过降低胆固醇合成和改变睾丸蛋白丙酰化来影响男性生殖衰老。胆固醇水平降低会影响胆固醇的修饰、睾酮的产生和生殖细胞膜的重塑。衰老相关的代谢紊乱也会影响体细胞和生精细胞之间的代谢耦合，导致男性生育能力下降。因此，我们假设甲羟戊酸途径的改变代表了生殖衰老的代谢原因之一。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Molecular Reproduction and Development 生物-发育生物学

CiteScore

5.20

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Molecular Reproduction and Development takes an integrated, systems-biology approach to understand the dynamic continuum of cellular, reproductive, and developmental processes. This journal fosters dialogue among diverse disciplines through primary research communications and educational forums, with the philosophy that fundamental findings within the life sciences result from a convergence of disciplines. Increasingly, readers of the Journal need to be informed of diverse, yet integrated, topics impinging on their areas of interest. This requires an expansion in thinking towards non-traditional, interdisciplinary experimental design and data analysis.