RETRACTED ARTICLE: Unleashing the Potential of Benincasa hispida Peel Extract: Synthesizing Selenium Nanoparticles with Remarkable Antibacterial and Anticancer Properties.

IF 3.2 4区 生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY
Molecular Biotechnology Pub Date : 2026-08-01 Epub Date: 2023-09-26 DOI:10.1007/s12033-023-00884-y
Salman Khan, Zeshan Rafi, Pooja Mishra, Lamya Ahmed Al-Keridis, Alvina Farooqui, Shazia Mansoor, Nawaf Alshammari, Fatimah A Al-Saeed, Samra Siddiqui, Mohd Saeed
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引用次数: 0
发挥蛇床子皮提取物的潜力:合成具有显著抗菌抗癌性能的硒纳米粒子。
在本研究中,我们采用环保的方法成功合成了硒纳米颗粒(P-SeNPs)。该方法包括将冬瓜的水性果皮提取物与硒盐结合使用。通过我们的创新程序,我们利用了黑热病固有的令人印象深刻的生物还原能力、治疗潜力和稳定特性。这导致形成具有独特和值得注意的品质的P-SeNP。我们的发现通过使用各种技术的全面表征得到了充分证实,包括紫外-可见光谱(UV-Vis)、透射电子显微镜(TEM)、动态光散射(DLS)、ζ电位分析和傅里叶变换红外光谱(FTIR)。纳米颗粒呈球形,尺寸相当大(22.32 ± 2nm)、均匀分布和显著的稳定性(-24mV),所有这些都表明了硬脊藻的植物成分的有效整合。此外,P-SeNPs对病原菌菌株表现出强大的抗菌功效,如其较低的最小抑制浓度值所示。我们的研究还揭示了P-SeNP对抗癌症的显著能力,其对HeLa细胞的IC50值为0.19µg/mL,令人印象深刻,同时对人类成骨细胞没有伤害,同时对人体成骨细胞也没有毒性。这些关键发现强调了P-SeNP的变革性质,它有望用于靶向抗菌治疗和癌症治疗的进步。这些纳米颗粒的意义延伸到了它们在治疗、诊断和各种生物医学环境中的潜在应用。值得注意的是,环境可持续的合成过程和卓越的性能使这项研究成为纳米医学领域的一个重要里程碑,为更具前景和健康的未来铺平了道路。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Molecular Biotechnology
Molecular Biotechnology 医学-生化与分子生物学
CiteScore
4.10
自引率
3.80%
发文量
165
审稿时长
6 months
期刊介绍: Molecular Biotechnology publishes original research papers on the application of molecular biology to both basic and applied research in the field of biotechnology. Particular areas of interest include the following: stability and expression of cloned gene products, cell transformation, gene cloning systems and the production of recombinant proteins, protein purification and analysis, transgenic species, developmental biology, mutation analysis, the applications of DNA fingerprinting, RNA interference, and PCR technology, microarray technology, proteomics, mass spectrometry, bioinformatics, plant molecular biology, microbial genetics, gene probes and the diagnosis of disease, pharmaceutical and health care products, therapeutic agents, vaccines, gene targeting, gene therapy, stem cell technology and tissue engineering, antisense technology, protein engineering and enzyme technology, monoclonal antibodies, glycobiology and glycomics, and agricultural biotechnology.
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