Depletion of dexamethasone in cattle: Food safety study in dairy and beef cattle

IF 1.5 4区 农林科学 Q3 PHARMACOLOGY & PHARMACY
Al Chicoine, David L. Renaud, Saad S. Enouri, Patricia M. Dowling, Yu Gu, Ron J. Johnson
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引用次数: 0

Abstract

Dexamethasone is approved for cattle in Canada for several conditions, but no withdrawal times are currently provided on the approved labels. Recently, the list of Maximum Residues Limits for Veterinary Drugs in Foods in Canada was amended to include dexamethasone. The objectives of this study were to determine the residue depletion profile of dexamethasone after an extra-label dosage regimen in milk of healthy lactating dairy cattle (n = 18) and in edible tissues of healthy beef cattle (n = 16) and to suggest withdrawal intervals. Dexamethasone was administered intramuscularly at 0.05 mg/kg daily for 3 days. Milk samples were collected prior to treatment and every 12 h up to 96 h post-dose. Muscle, liver, kidney, and peri-renal fat tissues were collected from beef cattle at 3, 7, 11, or 15 days post-dose. Dexamethasone analysis was performed by liquid chromatography/mass spectrophotometry. Dexamethasone residues were detected in milk samples up to 36 h. Muscle and fat had no detectable dexamethasone residues while kidney and liver had detectable residues only on day 3 post-dose. A withdrawal interval of 48 h for milk in Canadian dairy cattle and 7 days for meat in Canadian beef cattle are suggested for the dexamethasone treatment regimen most commonly requested to CgFARAD™.

Abstract Image

牛体内地塞米松的消耗:奶牛和肉牛的食品安全研究。
地塞米松在加拿大被批准用于多种条件下的牛,但目前批准的标签上没有提供停用时间。最近,加拿大对食品中兽药的最大残留限量进行了修订,将地塞米松纳入其中。本研究的目的是确定健康泌乳奶牛(n = 18) 以及在健康肉牛的可食用组织中(n = 16) 并建议退出间隔。在0.05时肌肉注射地塞米松 mg/kg,每日3次 天。在治疗前采集牛奶样本,每12个 h高达96 h给药后。从3、7、11或15岁的肉牛身上采集肌肉、肝脏、肾脏和肾周脂肪组织 给药后几天。采用液相色谱/质谱法对地塞米松进行分析。在多达36个牛奶样本中检测到地塞米松残留 h.肌肉和脂肪没有可检测的地塞米松残留,而肾脏和肝脏只有在给药后第3天才有可检测的残留。提款间隔48 h表示加拿大奶牛的乳汁和7 加拿大肉牛肉的天数建议用于CgFARAD最常见的地塞米松治疗方案™.
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来源期刊
CiteScore
3.10
自引率
15.40%
发文量
69
审稿时长
8-16 weeks
期刊介绍: The Journal of Veterinary Pharmacology and Therapeutics (JVPT) is an international journal devoted to the publication of scientific papers in the basic and clinical aspects of veterinary pharmacology and toxicology, whether the study is in vitro, in vivo, ex vivo or in silico. The Journal is a forum for recent scientific information and developments in the discipline of veterinary pharmacology, including toxicology and therapeutics. Studies that are entirely in vitro will not be considered within the scope of JVPT unless the study has direct relevance to the use of the drug (including toxicants and feed additives) in veterinary species, or that it can be clearly demonstrated that a similar outcome would be expected in vivo. These studies should consider approved or widely used veterinary drugs and/or drugs with broad applicability to veterinary species.
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