The utility of serum amyloid A and other acute-phase reactants determination in ambulatory care COVID-19 patients.

IF 2 4区医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Medical Biochemistry Pub Date : 2023-08-25 DOI:10.5937/jomb0-42799

Boris Jegorović, Aleksandra Nikolić, Neda Milinković, Svetlana Ignjatović, Sandra Šipetić-Grujičić

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Abstract

Background: The unpredictable course of Coronavirus Disease 19 (COVID-19) is making good severity assessment tools crucial. This study aimed to assess the usefulness of serum amyloid A (SAA) and other acute-phase reactants (APRs) in ambulatory care COVID-19 patients and identified relationships between these markers and disease outcomes.

Methods: From August to November 2020, patients seen in the outpatient department of the Clinic for Infectious and Tropical Diseases (Belgrade, Serbia) with confirmed COVID-19 were included. Patients were classified into mild, moderate, and severe disease groups based on World Health Organization criteria. SAA, C-reactive protein (CRP), interleukin-6 (IL-6), procalcitonin (PCT), ferritin, fibrinogen, D-dimer, albumin, and transferrin were measured. The median values of all APRs were compared between COVID-19 severity groups, hospitalized and non-hospitalized patients, and survivors and non-survivors. The Receiver operator characteristic (ROC) curve analysis was used for the classification characteristics assessment of individual APRs for the severity of illness, hospitalization, and survival.

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血清淀粉样蛋白A和其他急性相反应物测定在动态护理新冠肺炎患者中的应用。

背景：冠状病毒疾病19（新冠肺炎）的不可预测的过程使得良好的严重性评估工具至关重要。本研究旨在评估血清淀粉样蛋白A（SAA）和其他急性期反应物（APRs）在新冠肺炎门诊患者中的作用，并确定这些标志物与疾病结果之间的关系。方法：纳入2020年8月至11月在传染病和热带病诊所（塞尔维亚贝尔格莱德）门诊就诊的确诊新冠肺炎患者。根据世界卫生组织的标准，患者被分为轻度、中度和重度疾病组。测定SAA、C-反应蛋白（CRP）、白细胞介素-6（IL-6）、降钙素原（PCT）、铁蛋白、纤维蛋白原、D-二聚体、白蛋白和转铁蛋白。比较了新冠肺炎严重程度组、住院和非住院患者、幸存者和非幸存者之间所有APR的中值。受试者-操作者特征（ROC）曲线分析用于评估疾病严重程度、住院和生存率的个体APR的分类特征。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Medical Biochemistry BIOCHEMISTRY & MOLECULAR BIOLOGY-

CiteScore

3.00

自引率

12.00%

发文量

审稿时长

>12 weeks

期刊介绍： The JOURNAL OF MEDICAL BIOCHEMISTRY (J MED BIOCHEM) is the official journal of the Society of Medical Biochemists of Serbia with international peer-review. Papers are independently reviewed by at least two reviewers selected by the Editors as Blind Peer Reviews. The Journal of Medical Biochemistry is published quarterly. The Journal publishes original scientific and specialized articles on all aspects of clinical and medical biochemistry, molecular medicine, clinical hematology and coagulation, clinical immunology and autoimmunity, clinical microbiology, virology, clinical genomics and molecular biology, genetic epidemiology, drug measurement, evaluation of diagnostic markers, new reagents and laboratory equipment, reference materials and methods, reference values, laboratory organization, automation, quality control, clinical metrology, all related scientific disciplines where chemistry, biochemistry, molecular biology and immunochemistry deal with the study of normal and pathologic processes in human beings.