The effects of collagen cross-link deficiency on osseointegration process of pure titanium implants.

IF 4.3 3区材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC

ACS Applied Electronic Materials Pub Date : 2024-07-08 Epub Date: 2023-10-05 DOI:10.2186/jpr.JPR_D_22_00249

Mubarak Suliman, Masako Nagasawa, Farah A Al-Omari, Katsumi Uoshima

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引用次数: 0

Abstract

Purpose: This study aimed to investigate the effect of collagen cross-link deficiency on collagen fiber formation around an implant and its effect on the osseointegration process.

Methods: Wistar rats were fed 0.1% beta-aminopropionitrile (BAPN) dissolved in water to induce collagen cross-link deficiency. Custom-made mini-implants with machined surfaces were placed proximal to the tibia. At 1, 2, and 4 weeks postoperatively, the bone area around the implant, bone-implant contact ratio, osteoclast/osteocyte activity, and osseointegration strength were evaluated using histological and immunohistochemical analyses and biomechanical tests.

Results: Long-term disturbance of collagen cross-link formation in the BAPN group resulted in faster collagen fiber maturation than that in controls, with a defective collagen structure, low bone formation quantity, and low bone-implant contact values. Deficiency of collagen cross-links resulted in increased bone resorption and decreased osteocyte activity.

Conclusions: Collagen cross-linking is important for the formation of the collagen matrix, and their deficiency may impair bone activity around implants, affecting the osseointegration process.

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胶原交联缺乏对纯钛种植体骨整合过程的影响。

目的：本研究旨在研究胶原交联缺乏对种植体周围胶原纤维形成的影响及其对骨整合过程的影响。方法：Wistar大鼠喂食0.1%溶于水的β-氨基丙腈（BAPN）诱导胶原交联缺乏。定制的带有机械加工表面的微型植入物放置在胫骨附近。术后1、2和4周，使用组织学和免疫组织化学分析以及生物力学测试评估植入物周围的骨面积、骨植入物接触率、破骨细胞/骨细胞活性和骨整合强度。结果：BAPN组胶原交联形成的长期紊乱导致胶原纤维比对照组更快成熟，胶原结构有缺陷，骨形成量低，骨植入物接触值低。胶原交联的缺乏导致骨吸收增加和骨细胞活性降低。结论：胶原交联对胶原基质的形成很重要，它们的缺乏可能会损害种植体周围的骨活性，影响骨整合过程。

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来源期刊

ACS Applied Electronic Materials Multiple-

CiteScore

7.20

自引率

4.30%

发文量

567