Diagnostic Criteria and Etiopathogenesis of Type 2 Diabetes and Its Complications: Lessons from the Pima Indians

IF 3.2 3区医学 Q1 MEDICINE, GENERAL & INTERNAL

Presse Medicale Pub Date : 2023-09-30 DOI:10.1016/j.lpm.2023.104176

Helen C Looker , Douglas C Chang , Leslie J Baier , Robert L Hanson , Robert G Nelson

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Abstract

The Phoenix Epidemiology and Clinical Research Branch of the National Institute of Diabetes and Digestive and Kidney Diseases has conducted prospective studies of diabetes and its complications in the Pima Indians living in Arizona, USA for over 50 years. In this review we highlight areas in which these studies provided vital insights into the criteria used to diagnose type 2 diabetes, the pathophysiologic changes that accompany the development of type 2 diabetes, and the course and determinants of diabetes complications—focusing specifically on diabetic kidney disease. We include data from our longitudinal population-based study of diabetes and its complications, studies on the role of insulin resistance and insulin secretion in the pathophysiology of type 2 diabetes, and in-depth studies of diabetic kidney disease that include measures of glomerular function and research kidney biopsies. We also focus on the emerging health threat posed by youth-onset type 2 diabetes, which was first seen in the Pima Indians in the 1960s and is becoming an increasing issue worldwide.

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2型糖尿病及其并发症的诊断标准和病因：来自皮马印第安人的经验教训。

美国国家糖尿病、消化和肾脏疾病研究所凤凰城流行病学和临床研究分院对居住在美国亚利桑那州的皮马印第安人的糖尿病及其并发症进行了50多年的前瞻性研究。在这篇综述中，我们强调了这些研究为诊断2型糖尿病的标准、伴随2型糖尿病发展的病理生理变化以及糖尿病并发症的过程和决定因素提供了重要见解的领域，特别是糖尿病肾病。我们纳入了糖尿病及其并发症的纵向人群研究数据，胰岛素抵抗和胰岛素分泌在2型糖尿病病理生理学中作用的研究，以及糖尿病肾病的深入研究，包括肾小球功能测量和肾活检研究。我们还关注年轻人发病的2型糖尿病对健康构成的新威胁，这种糖尿病于20世纪60年代首次出现在皮马印第安人身上，并正在成为世界范围内日益严重的问题。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Presse Medicale 医学-医学：内科

自引率

3.70%

发文量

审稿时长

43 days

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