Circulating tumor cells and host immunity: A tricky liaison.

3区 生物学 Q1 Biochemistry, Genetics and Molecular Biology
Elena Muraro, Giulia Brisotto
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引用次数: 0

Abstract

During their dissemination, circulating tumor cells (CTCs) steadily face the immune system, which is a key player in the whole metastatic cascade, from intravasation to the CTC colonization of distant sites. In this chapter, we will go through the description of immune cells involved in this controversial dialogue encompassing both the anti-tumor activity and the tumor-promoting and immunosuppressive function mediated by several circulating immune effectors as natural killer (NK) cells, CD4+ and CD8+ T lymphocytes, T helper 17, regulatory T cells, neutrophils, monocytes, macrophages, myeloid-derived suppressor cells, dendritic cells, and platelets. Then, we will report on the same interaction from the CTCs point of view, depicting the direct and indirect mechanisms of crosstalk with the above mentioned immune cells. Finally, we will report the recent literature evidence on the potential prognostic role of the integrated CTCs and immune cells monitoring in cancer patients management.

循环肿瘤细胞和宿主免疫:一个棘手的联系。
在其扩散过程中,循环肿瘤细胞(CTC)稳定地面对免疫系统,免疫系统是整个转移级联的关键参与者,从浸润内到CTC在远处的定植。在本章中,我们将对参与这场有争议的对话的免疫细胞进行描述,包括抗肿瘤活性以及由几种循环免疫效应物介导的肿瘤促进和免疫抑制功能,如自然杀伤(NK)细胞、CD4+和CD8+T淋巴细胞、T辅助17、调节性T细胞、中性粒细胞、单核细胞、巨噬细胞,骨髓来源的抑制细胞、树突状细胞和血小板。然后,我们将从CTC的角度报道相同的相互作用,描述与上述免疫细胞串扰的直接和间接机制。最后,我们将报告关于综合CTC和免疫细胞监测在癌症患者管理中的潜在预后作用的最新文献证据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
International review of cell and molecular biology
International review of cell and molecular biology BIOCHEMISTRY & MOLECULAR BIOLOGY-CELL BIOLOGY
CiteScore
7.70
自引率
0.00%
发文量
67
审稿时长
>12 weeks
期刊介绍: International Review of Cell and Molecular Biology presents current advances and comprehensive reviews in cell biology-both plant and animal. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. Authored by some of the foremost scientists in the field, each volume provides up-to-date information and directions for future research.
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