Association Between the Attention Network Test, Neuropsychological Measures, and Disability in Post-Acute Traumatic Brain Injury.

IF 1.8 Q3 CLINICAL NEUROLOGY
Neurotrauma reports Pub Date : 2023-05-15 eCollection Date: 2023-01-01 DOI:10.1089/neur.2022.0068
Abhishek Jaywant, Emily Blunt, Keith Jamison, Nayoung Kim, Arindam RoyChoudhury, Nicholas D Schiff, Amy Kuceyeski, Kristen Dams-O'Connor, Sudhin Shah
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Abstract

Cognitive impairment after traumatic brain injury (TBI) is persistent and disabling. Assessing cognitive function in a reliable and valid manner, using measures that are sensitive to the integrity of underlying neural substrates, is crucial in clinical research. The Attention Network Test (ANT) is one such assessment measure that has demonstrated associations with neural regions involved in attention; however, clinical utility of the ANT is limited because its relationship with neuropsychological measures of cognitive function (i.e., its construct validity) has not yet been established in TBI. We evaluated the association between the ANT and 1) a neuropsychological battery assessing executive function and memory and 2) global function assessed by the Glasgow Outcome Scale-Extended (GOSE). Forty-eight adults with complicated mild-severe TBI were evaluated ∼5 months post-injury. Using principal component analysis and multi-variate linear regression adjusted for age, gender, education, and cause of injury, we found that ANT reaction time and executive network scores predicted a principal component assessing processing speed and executive function. Conversely, the ANT did not predict a principal component assessing memory. The ANT was weakly associated with the GOSE. Among persons with TBI during the post-acute phase of recovery, the ANT has good construct validity as evidenced by its associations with neuropsychological measures of processing speed and executive function, but not memory. Given that ANT networks are known to relate to specific neuroanatomical regions, the ANT may be a useful outcome measure for evaluating novel therapeutics targeting attention and executive functions after TBI.

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急性颅脑损伤后注意网络测试、神经心理学测量和残疾之间的关系。
创伤性脑损伤(TBI)后的认知障碍是持续的和致残的。以可靠有效的方式评估认知功能,使用对潜在神经基质完整性敏感的措施,在临床研究中至关重要。注意力网络测试(ANT)就是这样一种评估措施,它已经证明了与注意力相关的神经区域的关联;然而,ANT的临床应用是有限的,因为它与认知功能的神经心理学测量(即其结构有效性)的关系尚未在TBI中得到证实。我们评估了ANT与1)评估执行功能和记忆的神经心理组和2)通过格拉斯哥结果扩展量表(GOSE)评估的整体功能之间的关系。48名患有复杂轻度-重度TBI的成年人在受伤后~5个月接受了评估。使用主成分分析和根据年龄、性别、教育程度和受伤原因调整的多变量线性回归,我们发现ANT反应时间和执行网络得分预测了评估处理速度和执行功能的主成分。相反,ANT没有预测评估记忆的主要成分。ANT与GOSE的相关性较弱。在急性期后恢复期的TBI患者中,ANT具有良好的结构有效性,这可以通过其与处理速度和执行功能的神经心理学测量的关联来证明,但与记忆无关。鉴于已知ANT网络与特定的神经解剖学区域有关,ANT可能是评估TBI后针对注意力和执行功能的新疗法的有用结果指标。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
2.40
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0.00%
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