Role of vascular endothelial growth factor in tuberculous meningitis: A prospective study from a tertiary care center in North India.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-07-01 DOI:10.4103/ijp.ijp_743_22

Devesh Kumar, Deependra Singh, Tanish Modi, Riya Sharma, Anand Keshav Awasthy, Ritu Shree, Manoj Kumar Goyal, Dhawal Narang, Siddharth Chand, Sameer Vyas, Kusum Sharma, Navneet Sharma, Rudresh Gowda, Abeer Goel, Rajeev Ranjan, Manish Modi

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引用次数: 0

Abstract

Introduction: The status of vascular endothelial-derived growth factor (VEGF) in the pathogenesis of tuberculous meningitis (TBM) remains far from clear. We prospectively evaluated the role of serum and cerebrospinal fluid (CSF) VEGF in TBM.

Patients and methods: This prospective study was conducted at a tertiary care center in North India from January 2018 to June 2019. Consecutive drug-naive patients (n = 82) of TBM diagnosed on the basis of modified Ahuja's criteria were included in the study. The results were compared with 49 control subjects (n = 49). Serum and CSF VEGF were done in all the cases and controls. Follow-up serum VEGF levels were done in 34 patients after 3 months of completion of antitubercular therapy. The VEGF levels were estimated using the human VEGF enzyme-linked immunosorbent assay kit.

Results: The mean age was 29.9 ± 13.1 years. The study group consisted of 33 (40.2%) men and 49 (59.8%) women. BACTEC MGIT960 was positive in 15 (18%) patients while multiplex tuberculosis polymerase chain reaction was positive in 73 (89%) patients. Levels of VEGF in serum and CSF of TBM patients were not elevated when compared to controls. There was no association between final outcome in TBM and decrease in serum levels of VEGF at follow-up.

Conclusion: VEGF may not be playing a significant role in the pathogenesis of TBM. Future studies with larger sample size may clarify the status of VEGF further in TBM.

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血管内皮生长因子在结核性脑膜炎中的作用：来自北印度一家三级护理中心的前瞻性研究。

引言：血管内皮衍生生长因子（VEGF）在结核性脑膜炎（TBM）发病机制中的地位尚不清楚。我们前瞻性评估了血清和脑脊液（CSF）VEGF在TBM中的作用。患者和方法：这项前瞻性研究于2018年1月至2019年6月在北印度的一家三级护理中心进行。根据改良的Ahuja标准诊断的连续未服用药物的TBM患者（n=82）被纳入研究。将结果与49名对照受试者（n=49）进行比较。所有病例和对照组均进行血清和CSF VEGF检测。34名患者在完成抗结核治疗3个月后进行了血清VEGF水平的随访。使用人VEGF酶联免疫吸附测定试剂盒估计VEGF水平。结果：平均年龄29.9±13.1岁。研究组包括33名（40.2%）男性和49名（59.8%）女性。BACTEC MGIT960在15例（18%）患者中呈阳性，而多重结核聚合酶链反应在73例（89%）患者中阳性。与对照组相比，TBM患者血清和CSF中的VEGF水平没有升高。TBM的最终结果与随访时血清VEGF水平的下降之间没有关联。结论：VEGF可能在TBM的发病机制中没有发挥重要作用。未来更大样本量的研究可能会进一步阐明VEGF在TBM中的地位。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.