Blood-Based Biomarkers for Neuroprognostication in Acute Brain Injury.

IF 1.8 4区医学 Q3 CLINICAL NEUROLOGY

Seminars in Neurology Pub Date : 2023-10-01 Epub Date: 2023-09-26 DOI:10.1055/s-0043-1775764

Andrew M Nguyen, Vishal Saini, H E Hinson

引用次数: 0

Abstract

Acute brain injury causes loss of functionality in patients that often is devastating. Predicting the degree of functional loss and overall prognosis requires a multifaceted approach to help patients, and more so their families, make important decisions regarding plans and goals of care. A variety of blood-based markers have been studied as one aspect of this determination. In this review, we discuss CNS-derived and systemic markers that have been studied for neuroprognostication purposes. We discuss the foundation of each protein, the conditions in which it has been studied, and how the literature has used these markers for interpretation. We also discuss challenges to using each marker in each section as well.

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急性脑损伤神经诊断的血液生物标志物。

急性脑损伤会导致患者丧失功能，这通常是毁灭性的。预测功能丧失的程度和总体预后需要多方面的方法来帮助患者，尤其是他们的家人，就护理计划和目标做出重要决定。作为这种测定的一个方面，已经研究了各种基于血液的标志物。在这篇综述中，我们讨论了中枢神经系统衍生和系统性标记物，这些标记物已被研究用于神经诊断目的。我们讨论了每种蛋白质的基础、研究条件，以及文献如何使用这些标记进行解释。我们还讨论了在每一节中使用每个标记的挑战。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Seminars in Neurology 医学-临床神经学

CiteScore

4.60

自引率

3.70%

发文量

审稿时长

6-12 weeks

期刊介绍： Seminars in Neurology is a review journal on current trends in the evaluation, diagnosis, and treatment of neurological diseases. Areas of coverage include multiple sclerosis, central nervous system infections, muscular dystrophy, neuro-immunology, spinal disorders, strokes, epilepsy, motor neuron diseases, movement disorders, higher cortical function, neuro-genetics and neuro-ophthamology. Each issue is presented under the direction of an expert guest editor, and invited contributors focus on a single, high-interest clinical topic. Up-to-the-minute coverage of the latest information in the field makes this journal an invaluable resource for neurologists and residents.