Population analysis of the CLOCK rs3749474T-rs4864548A haplotype and its relationship with obesity.

IF 1.2 Q2 MEDICINE, GENERAL & INTERNAL

Medwave Pub Date : 2023-10-03 DOI:10.5867/medwave.2023.09.2735

Sergio Flores Carrasco, Mariela Olguín-Barraza, Angel Roco-Videla

引用次数: 0

Abstract

It has been suggested that the rs3749474T/rs4864548A haplotype of the CLOCK gene increases the risk of obesity, but the population variability of these alleles and the haplotype is unknown. This research aims to determine the linkage between the rs3749474T and rs4864548A alleles from the database of 1000Genomes to confirm the existence of the TA haplotype polymorphisms of these alleles and their frequency in five macro populations. Linkage disequilibrium and haplotype frequencies for 2504 individuals from 26 populations were analyzed using the r statistic and Fisher's exact test. There is a high frequency of the TA haplotype in Latin America (44.8%), a high linkage disequilibrium (r2= 0.92) worldwide between these alleles, a high differentiation between macro populations, and a high homogeneity. The evidence warrants further studies on the association between this haplotype and the risk of obesity and overweight in Latin American populations.

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CLOCK rs3749474T-rs4865488A单倍型的群体分析及其与肥胖的关系。

有人认为，CLOCK基因的rs3749474T/rs4865488A单倍型会增加肥胖的风险，但这些等位基因和单倍型的群体变异性尚不清楚。本研究旨在从1000基因组数据库中确定rs3749474T和rs4865488A等位基因之间的连锁，以证实这些等位基因的TA单倍型多态性的存在及其在五个大群体中的频率。使用r统计量和Fisher精确检验分析了来自26个群体的2504个个体的连锁不平衡和单倍型频率。TA单倍型在拉丁美洲的频率很高（44.8%），在全世界这些等位基因之间存在高度连锁不平衡（r2=0.92），宏观群体之间存在高度分化，并且具有高度同质性。这些证据支持对这种单倍型与拉丁美洲人群肥胖和超重风险之间的关系进行进一步研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Medwave MEDICINE, GENERAL & INTERNAL-

CiteScore

2.60

自引率

8.30%

发文量

审稿时长

12 weeks

期刊介绍： Medwave is a peer-reviewed, biomedical and public health journal. Since its foundation in 2001 (Volume 1) it has always been an online only, open access publication that does not charge subscription or reader fees. Since January 2011 (Volume 11, Number 1), all articles are peer-reviewed. Without losing sight of the importance of evidence-based approach and methodological soundness, the journal accepts for publication articles that focus on providing updates for clinical practice, review and analysis articles on topics such as ethics, public health and health policy; clinical, social and economic health determinants; clinical and health research findings from all of the major disciplines of medicine, medical science and public health. The journal does not publish basic science manuscripts or experiments conducted on animals. Until March 2013, Medwave was publishing 11-12 numbers a year. Each issue would be posted on the homepage on day 1 of each month, except for Chile’s summer holiday when the issue would cover two months. Starting from April 2013, Medwave adopted the continuous mode of publication, which means that the copyedited accepted articles are posted on the journal’s homepage as they are ready. They are then collated in the respective issue and included in the Past Issues section.