Sara Vela-Bernal, Rita Facchetti, Raffaella Dell'Oro, Fosca Quarti-Trevano, Empar Lurbe, Giuseppe Mancia, Guido Grassi
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引用次数: 0
Abstract
The present study was designed to provide information on the ability of several different anthropometric markers to reflect the renal impairment associated with body weight increase and to predict the development of renal alterations linked to overweight and obesity. In 574 subjects representative of the general population of the Pressioni Arteriose Monitorate e Loro Associazioni (PAMELA) study, with an age range between 57 and 73 years, we investigated the association between different anthropometric markers of body fat, as alternative to body mass index, and renal failure, to obtain information useful for determining their potential predictive value. Renal dysfunction was significantly associated with almost all anthropometric markers of adiposity related to body weight and body shape. After adjustment for confounders, such as age, sex, office blood pressure, serum glucose, antihypertensive drugs and smoking habit, association remained significant only for waist-to-hip ratio (WHR), lipid accumulation product (LAP) and visceral adiposity index (VAI). These 3 markers also displayed at the receiver operating curves (ROC) analysis the best ability to detect subjects with or without kidney dysfunction. The results of the present study provide evidence that WHR, LAP and VAI represent the best markers of renal dysfunction associated with visceral body fat accumulation.
本研究旨在提供几种不同人体测量标志物的能力信息,以反映与体重增加相关的肾脏损伤,并预测与超重和肥胖相关的肾脏改变的发展。在574名年龄在57岁至73岁之间的代表Pressioni Arteriose Monitoring e Loro Associazioni(PAMELA)研究普通人群的受试者中,我们调查了不同的体脂人体测量标志物(代替体重指数)与肾衰竭之间的关系,以获得有助于确定其潜在预测价值的信息。肾功能障碍与几乎所有与体重和体型相关的肥胖人体测量标志物显著相关。在校正了年龄、性别、办公室血压、血糖、降压药和吸烟习惯等混杂因素后,只有腰臀比(WHR)、脂质堆积产物(LAP)和内脏肥胖指数(VAI)的相关性仍然显著。这3个标志物在受试者工作曲线(ROC)分析中也显示出检测有或没有肾功能障碍的受试者的最佳能力。本研究的结果提供了证据,证明WHR、LAP和VAI是与内脏脂肪积聚相关的肾功能障碍的最佳标志物。
期刊介绍:
High Blood Pressure & Cardiovascular Prevention promotes knowledge, update and discussion in the field of hypertension and cardiovascular disease prevention, by providing a regular programme of independent review articles covering key aspects of the management of hypertension and cardiovascular diseases. The journal includes: Invited ''State of the Art'' reviews. Expert commentaries on guidelines, major trials, technical advances.Presentation of new intervention trials design.''Pros and Cons'' or round tables on controversial issues.Statements on guidelines from hypertension and cardiovascular scientific societies.Socio-economic issues.Cost/benefit in prevention of cardiovascular diseases.Monitoring of healthcare systems.News and views from the Italian Society of Hypertension (including abstracts).All manuscripts are subject to peer review by international experts. Letters to the editor are welcomed and will be considered for publication.