Forces and Flows at Cell Surfaces.

IF 2.3 4区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Membrane Biology Pub Date : 2023-12-01 Epub Date: 2023-09-29 DOI:10.1007/s00232-023-00293-x

Aurelia R Honerkamp-Smith

引用次数: 0

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细胞表面的力和流。

流量是一种重要的生理信号，调节多种细胞功能。然而，细胞用来感知流动的分子机制仍然令人惊讶地不透明。流量传感的第一步可能发生在质膜上，质膜是细胞内外之间的流体屏障。这种膜是一种有组织的二维分子阵列，具有固体和流体性质。膜蛋白和脂质的移动性受到与支持膜的细胞骨架蛋白网络的复杂相互作用的限制。与生理相关的流动只能在单个蛋白质上产生微小的力，比热噪声产生的力更小。然而，细胞可以通过检测细胞外膜蛋白的微米级浓度梯度来克服这个问题。这在细胞质膜中是可能的，因为它们的特殊物理状态允许流动在细胞外表面上对膜蛋白进行横向分类。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Membrane Biology 生物-生化与分子生物学

CiteScore

4.80

自引率

4.20%

发文量

审稿时长

6-12 weeks

期刊介绍： The Journal of Membrane Biology is dedicated to publishing high-quality science related to membrane biology, biochemistry and biophysics. In particular, we welcome work that uses modern experimental or computational methods including but not limited to those with microscopy, diffraction, NMR, computer simulations, or biochemistry aimed at membrane associated or membrane embedded proteins or model membrane systems. These methods might be applied to study topics like membrane protein structure and function, membrane mediated or controlled signaling mechanisms, cell-cell communication via gap junctions, the behavior of proteins and lipids based on monolayer or bilayer systems, or genetic and regulatory mechanisms controlling membrane function. Research articles, short communications and reviews are all welcome. We also encourage authors to consider publishing ''negative'' results where experiments or simulations were well performed, but resulted in unusual or unexpected outcomes without obvious explanations. While we welcome connections to clinical studies, submissions that are primarily clinical in nature or that fail to make connections to the basic science issues of membrane structure, chemistry and function, are not appropriate for the journal. In a similar way, studies that are primarily descriptive and narratives of assays in a clinical or population study are best published in other journals. If you are not certain, it is entirely appropriate to write to us to inquire if your study is a good fit for the journal.