Epicardial Fat Volume as a Good Predictor for Multivessel Coronary Artery Disease.

IF 3.1 Q2 PERIPHERAL VASCULAR DISEASE
Eman S El Shahawy, Asmaa A Hassan, Mohamed S El Shahawy
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引用次数: 0

Abstract

Introduction: Epicardial adipose tissue may have an important role in the pathogenesis of coronary artery disease (CAD).

Aim: We aimed to study the association between epicardial fat volume (EFV) and presence of obstructive as well as multivessel CAD.

Methods: A total of 87 adult subjects with suspected CAD who underwent both quantified by multidetector computerized tomography (MDCT) and Invasive Coronary Angiography (ICA) were enrolled in this observational study. EVF was measured by MDCT by calculating the sum of cross- sectional areas of fat multiplied by slice thickness. EFV measurement and its association with the presence of obstructive CAD (defined as coronary artery stenosis > 70%) was evaluated.

Results: Overall, 89.6% patients had obstructive CAD with higher EFV as compared to 10.3% patients with non-obstructive CAD (57 ± 20.14 cm3 vs. 44 ± 7.4 cm3; P < 0.001). Furthermore, EFV was significantly increased in group II as compared with group I (74 ± 24.3 ml vs. 53 ± 16.2 ml; P < 0.003). On the hand, the coronary calcium score (CAC) was insignificantly increased in group II as compared with group I (486.1 vs. 211.2; P = 0.10). Multivariate analysis revealed that, EFV might be an independent risk factor for not only the presence of obstructive CAD (odds ratio [OR], 1.062; 95% CI 1.018- 1.108; P < 0.005) but also in predicting multivessel disease affection.

Conclusions: Our results demonstrated that, EFV was significantly increased not only with obstructive CAD, independent of other traditional risk factors and CAC score, but also it can be considered a good predictor of multivessel disease occurrence.

心外膜脂肪体积是多血管冠状动脉疾病的良好预测指标。
引言:心外膜脂肪组织可能在冠状动脉疾病(CAD)的发病机制中发挥重要作用。目的:我们旨在研究心外膜脂肪体积(EFV)与梗阻性和多血管CAD之间的关系。方法:共有87名疑似CAD的成年受试者参加了这项观察性研究,他们接受了多探测器计算机断层扫描(MDCT)和有创冠状动脉造影(ICA)的量化。EVF是通过MDCT计算脂肪横截面积之和乘以切片厚度来测量的。EFV测量及其与梗阻性CAD(定义为冠状动脉狭窄)的相关性 > 70%)。结果:总体而言,89.6%的患者患有EFV较高的梗阻性CAD,而非梗阻性CAD患者为10.3%(57 ± 20.14 cm3与44 ± 7.4立方厘米;P 结论:我们的研究结果表明,EFV不仅在梗阻性CAD中显著增加,与其他传统危险因素和CAC评分无关,而且可以被认为是多血管疾病发生的良好预测指标。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
5.70
自引率
3.30%
发文量
57
期刊介绍: High Blood Pressure & Cardiovascular Prevention promotes knowledge, update and discussion in the field of hypertension and cardiovascular disease prevention, by providing a regular programme of independent review articles covering key aspects of the management of hypertension and cardiovascular diseases. The journal includes:   Invited ''State of the Art'' reviews.  Expert commentaries on guidelines, major trials, technical advances.Presentation of new intervention trials design.''Pros and Cons'' or round tables on controversial issues.Statements on guidelines from hypertension and cardiovascular scientific societies.Socio-economic issues.Cost/benefit in prevention of cardiovascular diseases.Monitoring of healthcare systems.News and views from the Italian Society of Hypertension (including abstracts).All manuscripts are subject to peer review by international experts. Letters to the editor are welcomed and will be considered for publication.
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