The Efficacy of 480 ml Oral Sodium Sulfate for Improving Insufficient Bowel Preparation of Colonoscopy with High-Concentrated Polyethylene Glycol.

IF 2 4区医学 Q3 GASTROENTEROLOGY & HEPATOLOGY

Gastroenterology Research and Practice Pub Date : 2023-09-30 eCollection Date: 2023-01-01 DOI:10.1155/2023/6359165

Naohisa Yoshida, Yoshikazu Inagaki, Daisuke Hasegawa, Reo Kobayashi, Yuri Tomita, Hikaru Hashimoto, Ryohei Hirose, Osamu Dohi, Ken Inoue, Yasutaka Morimoto, Yutaka Inada, Takaaki Murakami, Yoshito Itoh

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引用次数: 0

Abstract

Objectives: Oral sulfate solution (OSS) is used for bowel preparation (BP) during colonoscopy. The way of taking this agent can be used a same-day regimen (only on the day of colonoscopy) and split regimen (the day before and on the day of colonoscopy) for receiving it. In this study, we analyzed the efficacy of a same-day regimen of 480 ml OSS for insufficient bowel preparation (BP) with high-concentrated polyethylene glycol (H-PEG).

Materials and methods: This multicenter retrospective study was conducted from December 2021 to December 2022 at three related institutions on patients aged ≥ 20 years with a fair or poor Aronchick score of BP with 1 l H-PEG in previous colonoscopy. All patients received a low-residual diet and 10 ml of 0.75% picosulfate sodium a day before the colonoscopy and 480 ml of OSS and ≥1 l of water 3 hours before the colonoscopy. We analyzed the rate of improvement with OSS compared to H-PEG and other efficacies, and adverse events (AE).

Results: We evaluated 125 cases (77 males) with an average age of 72.1 ± 8.8 years. The completion rate of 480 ml of OSS was 97.6% (122/125). The improvement rate of BP showing good or excellent score with OSS was 70.4% (88/125). Compared OSS with previous H-PEG, the insertion time (min) was 7.0 ± 4.8 vs. 8.1 ± 6.0 (p = 0.01), and the adenoma detection rates were 67.2% vs. 63.2% (p = 0.05). The cleansing time (min) was 131 ± 46 vs. 165 ± 53 (p < 0.01). The rate of AE with OSS was 10.4% (13/125). There were no significant differences about AE in age and gender. The tolerance of OSS compared with H-PEG (good/similar/bad) was 72.0%/24.8%/3.2% (amounts), 26.4%/39.2%/34.4% (taste), and 76.8%/10.4%/12.8% (overall preference), respectively.

Conclusions: The same-day regimen of 480 ml OSS effectively improved the insufficient BP of 1 l H-PEG.

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480的功效 ml口服硫酸钠改善肠道不适高浓度聚乙二醇结肠镜检查准备。

目的：口服硫酸溶液（OSS）用于结肠镜检查期间的肠道准备（BP）。服用该药物的方式可以采用当天方案（仅在结肠镜检查当天）和分体式方案（结肠镜检查前一天和当天）。在本研究中，我们分析了480 ml OSS治疗高浓度聚乙二醇（H-PEG）肠道准备不足（BP）。材料和方法：这项多中心回顾性研究于2021年12月至2022年12月在三家相关机构对年龄≥20岁的患者进行，患者的Aroncick评分为1 l既往结肠镜检查中的H-PEG。所有患者均接受低残留饮食和10 结肠镜检查前一天服用0.75%皮硫酸钠ml，480 ml OSS且≥1 l结肠镜检查前3小时的水。我们分析了OSS与H-PEG相比的改善率和其他疗效，以及不良事件（AE）。结果：我们评估了125例（77名男性），平均年龄为72.1±8.8岁。480的完成率 ml OSS的阳性率为97.6%（122/125）。OSS评分良好或优良的BP改善率为70.4%（88/125）。OSS与以往H-PEG比较，插入时间（min）为7.0±4.8 vs.8.1±6.0（p=0.01），腺瘤检出率为67.2%vs.63.2%（p=0.05），清洗时间（min）为131±46 vs.165±53（p<0.01），OSS AE发生率为10.4%（13/125）。AE在年龄和性别上无显著差异。OSS与H-PEG（好/相似/坏）相比的耐受性分别为72.0%/24.8%/3.2%（量）、26.4%/39.2%/34.4%（味道）和76.8%/10.4%/12.8%（总体偏好）。结论：480的同一天方案 ml OSS有效改善了1 l H-PEG。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Gastroenterology Research and Practice GASTROENTEROLOGY & HEPATOLOGY-

CiteScore

4.40

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： Gastroenterology Research and Practice is a peer-reviewed, Open Access journal which publishes original research articles, review articles and clinical studies based on all areas of gastroenterology, hepatology, pancreas and biliary, and related cancers. The journal welcomes submissions on the physiology, pathophysiology, etiology, diagnosis and therapy of gastrointestinal diseases. The aim of the journal is to provide cutting edge research related to the field of gastroenterology, as well as digestive diseases and disorders. Topics of interest include: Management of pancreatic diseases Third space endoscopy Endoscopic resection Therapeutic endoscopy Therapeutic endosonography.