A crosswalk on the genetic and conventional strategies for enhancing astaxanthin production in Haematococcus pluvialis.

IF 8.1 2区 工程技术 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Critical Reviews in Biotechnology Pub Date : 2024-09-01 Epub Date: 2023-10-01 DOI:10.1080/07388551.2023.2240009
Adolf Acheampong, Lamei Li, Shereen M Elsherbiny, Yahui Wu, Mohammed Sharif Swallah, Precious Bondzie-Quaye, Qing Huang
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引用次数: 0

Abstract

Astaxanthin is a naturally occurring xanthophyll with powerful: antioxidant, antitumor, and antibacterial properties that are widely employed in food, feed, medicinal and nutraceutical industries. Currently, chemical synthesis dominates the world's astaxanthin market, but the increasing demand for natural products is shifting the market for natural astaxanthin. Haematococcus pluvialis (H. pluvialis) is the factory source of natural astaxanthin when grown in optimal conditions. Currently, various strategies for the production of astaxanthin have been proposed or are being developed in order to meet its market demand. This up-to-date review scrutinized the current approaches or strategies that aim to increase astaxanthin yield from H. pluvialis. We have emphasized the genetic and environmental parameters that increase astaxanthin yield. We also looked at the transcriptomic dynamics caused by environmental factors (phytohormones induction, light, salt, temperature, and nutrient starvation) on astaxanthin synthesizing genes and other metabolic changes. Genetic engineering and culture optimization (environmental factors) are effective approaches to producing more astaxanthin for commercial purposes. Genetic engineering, in particular, is accurate, specific, potent, and safer than conventional random mutagenesis approaches. New technologies, such as CRISPR-Cas9 coupled with omics and emerging computational tools, may be the principal strategies in the future to attain strains that can produce more astaxanthin. This review provides accessible data on the strategies to increase astaxanthin accumulation natively. Also, this review can be a starting point for new scholars interested in H. pluvialis research.

关于提高雨生红球藻虾青素产量的遗传和常规策略的人行横道。
虾青素是一种天然存在的叶黄素,具有强大的抗氧化、抗肿瘤和抗菌特性,广泛应用于食品、饲料、医药和营养品行业。目前,化学合成在世界虾青素市场上占据主导地位,但对天然产品日益增长的需求正在改变天然虾青素的市场。雨生红球藻(H.pluvialis)是在最佳条件下生长的天然虾青素的工厂来源。目前,为了满足市场需求,已经提出或正在开发生产虾青素的各种策略。这篇最新的综述仔细审查了目前旨在提高雨洪藻虾青素产量的方法或策略。我们强调了提高虾青素产量的遗传和环境参数。我们还研究了环境因素(植物激素诱导、光照、盐、温度和营养饥饿)对虾青素合成基因和其他代谢变化造成的转录组动力学。基因工程和培养优化(环境因素)是生产更多虾青素用于商业目的的有效方法。特别是基因工程比传统的随机诱变方法准确、特异、有效且安全。新技术,如CRISPR-Cas9,结合组学和新兴的计算工具,可能是未来获得能够产生更多虾青素的菌株的主要策略。这篇综述提供了关于增加虾青素天然积累的策略的可访问数据。此外,这篇综述也可以作为对雨洪藻研究感兴趣的新学者的起点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Critical Reviews in Biotechnology
Critical Reviews in Biotechnology 工程技术-生物工程与应用微生物
CiteScore
20.80
自引率
1.10%
发文量
71
审稿时长
4.8 months
期刊介绍: Biotechnological techniques, from fermentation to genetic manipulation, have become increasingly relevant to the food and beverage, fuel production, chemical and pharmaceutical, and waste management industries. Consequently, academic as well as industrial institutions need to keep abreast of the concepts, data, and methodologies evolved by continuing research. This journal provides a forum of critical evaluation of recent and current publications and, periodically, for state-of-the-art reports from various geographic areas around the world. Contributing authors are recognized experts in their fields, and each article is reviewed by an objective expert to ensure accuracy and objectivity of the presentation.
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